Ortega-Del Vecchyo Diego, Marsden Clare D, Lohmueller Kirk E
Interdepartmental Program in Bioinformatics, University of California, Los Angeles, CA 90095, USA.
Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA 90095, USA.
Bioinformatics. 2016 Nov 15;32(22):3516-3518. doi: 10.1093/bioinformatics/btw478. Epub 2016 Jul 19.
The Poisson Random Field (PRF) model has become an important tool in population genetics to study weakly deleterious genetic variation under complicated demographic scenarios. Currently, there are no freely available software applications that allow simulation of genetic variation data under this model. Here we present PReFerSim, an ANSI C program that performs forward simulations under the PRF model. PReFerSim models changes in population size, arbitrary amounts of inbreeding, dominance and distributions of selective effects. Users can track summaries of genetic variation over time and output trajectories of selected alleles.
PReFerSim is freely available at: https://github.com/LohmuellerLab/PReFerSim CONTACT: klohmueller@ucla.eduSupplementary information: Supplementary data are available at Bioinformatics online.
泊松随机场（PRF）模型已成为群体遗传学中研究复杂人口统计学情景下弱有害遗传变异的重要工具。目前，没有免费的软件应用程序能够在此模型下模拟遗传变异数据。在此，我们展示了PReFerSim，这是一个用ANSI C编写的程序，可在PRF模型下进行正向模拟。PReFerSim能够模拟种群大小的变化、任意程度的近亲繁殖、显性以及选择效应的分布。用户可以追踪遗传变异随时间的汇总情况，并输出选定等位基因的轨迹。
PReFerSim可在以下网址免费获取：https://github.com/LohmuellerLab/PReFerSim 联系方式：klohmueller@ucla.edu 补充信息：补充数据可在《生物信息学》在线版获取。
