弯曲杆菌鞭毛蛋白的体内抗原变异
In vivo antigenic variation of Campylobacter flagellin.
作者信息
Logan S M, Guerry P, Rollins D M, Burr D H, Trust T J
机构信息
Department of Biochemistry and Microbiology, University of Victoria, British Columbia, Canada.
出版信息
Infect Immun. 1989 Aug;57(8):2583-5. doi: 10.1128/iai.57.8.2583-2585.1989.
Campylobacter coli VC167 cells producing either antigenic phase 1 (P1) or phase 2 (P2) flagellins (as determined by characteristic protein and DNA patterns) were used to infect rabbits by the removable intestinal tie-adult rabbit diarrhea (RITARD) procedure. Rabbits infected with P2 cells shed predominantly P2 cells throughout the infection; in rabbits infected with P1 cells, a transition of fecal isolates from P1 to P2 was observed.
产生抗原1期（P1）或2期（P2）鞭毛蛋白的空肠弯曲菌VC167细胞（由特征性蛋白质和DNA模式确定）通过可移除肠结扎-成年兔腹泻（RITARD）程序用于感染兔子。感染P2细胞的兔子在整个感染过程中主要排出P2细胞；在感染P1细胞的兔子中，观察到粪便分离物从P1向P2的转变。
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