Staten M A, Totty W G, Kohrt W M
Section of Applied Physiology, Washington University School of Medicine, St. Louis, Missouri.
Invest Radiol. 1989 May;24(5):345-9. doi: 10.1097/00004424-198905000-00002.
Because of the important role of intra-abdominal fat in predicting increased risk for diabetes, hypertension, and heart disease, methods to quantify intra-abdominal fat are needed. Computed tomography defines quantity of intra-abdominal fat but is associated with significant radiation risk. We explored using magnetic resonance imaging (MRI) to measure amount and distribution of intra-abdominal fat. Because MRI has no known risk, the same subject can be studied repeatedly. Six subjects with percent body fat ranging from 14% to 44% had MRI scans of the chest, abdomen, and thigh on two separate occasions. Total abdominal fat and subcutaneous abdominal fat correlated with percent total body fat as determined from hydrostatic weighing (r = .99, P less than .001). Intra-abdominal fat correlated with the ratio of widest abdominal to widest hip circumference (r = .85, P less than .05). Reproducibility of the MRI measurements of fat was less than 3% for total body areas, less than 5% for subcutaneous fat areas, and less than 10% for internal fat areas. Reproducibility was better in individuals with higher percent total body fat. We conclude that MRI can reliably measure fat areas with no radiation risk to the patient.
由于腹内脂肪在预测糖尿病、高血压和心脏病风险增加方面具有重要作用，因此需要量化腹内脂肪的方法。计算机断层扫描可定义腹内脂肪量，但与显著的辐射风险相关。我们探索使用磁共振成像（MRI）来测量腹内脂肪的数量和分布。由于MRI不存在已知风险，同一受试者可反复进行研究。六名体脂百分比在14%至44%之间的受试者在两个不同时间分别进行了胸部、腹部和大腿的MRI扫描。腹部总脂肪和皮下腹部脂肪与通过静水称重法测定的全身脂肪百分比相关（r = 0.99，P小于0.001）。腹内脂肪与腹部最宽处与髋部最宽处的周长比相关（r = 0.85，P小于0.05）。全身脂肪区域的MRI测量重复性小于3%，皮下脂肪区域小于5%，内部脂肪区域小于10%。全身脂肪百分比越高的个体，重复性越好。我们得出结论，MRI能够可靠地测量脂肪区域，且对患者无辐射风险。
