Am J Epidemiol. 2015 Jun 1;181(11):846-56. doi: 10.1093/aje/kwv021. Epub 2015 Apr 21.
We aimed to investigate whether dietary intake of total or individual (n-3, n-6, and n-3:n-6 ratio) polyunsaturated fatty acids (PUFAs) was prospectively associated with serum levels of C-reactive protein (CRP), a marker of inflammation. We analyzed 4,707 participants (1,943 men and 2,764 women) from the Rotterdam Study, a prospective follow-up study of subjects aged 55 years or older in the Netherlands. At baseline (1989-1993), dietary intake of PUFAs was assessed by validated food frequency questionnaire. CRP was measured at baseline and at the third study visit (1997-1999). Regression coefficients (β) and 95% confidence intervals were obtained using linear generalized estimating equations. Dietary intake of butter and margarine explained most of the variance in PUFA intake. After adjustment for possible confounding factors, higher intake of total PUFAs was associated with lower CRP levels (fourth quartile vs. first quartile: β = -0.08, 95% confidence interval: -0.15, -0.01). Similarly, intake of n-6 PUFAs was inversely related to CRP (fourth quartile vs. first: β = -0.09, 95% confidence interval: -0.16, -0.01). No consistent trends were observed regarding n-3 PUFAs or n-3:n-6 PUFA ratio and CRP. These findings suggest that high intakes of total PUFAs are associated with lower levels of CRP, reflecting diminished chronic systemic inflammation, which in our study was mainly driven by n-6 PUFAs.
我们旨在研究总多不饱和脂肪酸（PUFA）或个体（n-3、n-6 和 n-3:n-6 比值）多不饱和脂肪酸的饮食摄入量是否与 C 反应蛋白（CRP）的血清水平呈前瞻性相关，CRP 是炎症的标志物。我们分析了来自荷兰鹿特丹研究的 4707 名参与者（男性 1943 名，女性 2764 名），这是一项针对年龄在 55 岁或以上的受试者的前瞻性随访研究。在基线（1989-1993 年）时，通过验证的食物频率问卷评估了 PUFAs 的饮食摄入量。在基线和第三次研究访问（1997-1999 年）时测量 CRP。使用线性广义估计方程获得回归系数（β）和 95%置信区间。黄油和人造黄油的饮食摄入量解释了 PUFAs 摄入量的大部分差异。在调整了可能的混杂因素后，总 PUFAs 的摄入量越高，CRP 水平越低（第四四分位数与第一四分位数相比：β=-0.08，95%置信区间：-0.15，-0.01）。同样，n-6 PUFAs 的摄入量与 CRP 呈负相关（第四四分位数与第一四分位数相比：β=-0.09，95%置信区间：-0.16，-0.01）。关于 n-3 PUFAs 或 n-3:n-6 PUFA 比值与 CRP 之间没有观察到一致的趋势。这些发现表明，总 PUFAs 的高摄入量与 CRP 水平降低有关，这反映了慢性全身性炎症的减轻，在我们的研究中，这主要是由 n-6 PUFAs 驱动的。
