Mejía-Rentería Hernán David, Núñez-Gil Iván J
Hernán David Mejía-Rentería, Servicio de Cardiología, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, 28805 Madrid, Spain.
World J Cardiol. 2016 Jul 26;8(7):413-24. doi: 10.4330/wjc.v8.i7.413.
Takotsubo cardiomyopathy is a syndrome mimicking an acute myocardial infarction in absence of obstructive epicardial coronary artery disease to explain the degree of the wall motion abnormalities. Typically more common in the elderly women, this condition is usually triggered by unexpected emotional or physical stress situations, and is associated with electrocardiogram abnormalities and slight elevation of cardiac biomarkers. The pathophysiological mechanism is not clear yet, but it is believed that a high circulating concentration of catecholamines causes an acute dysfunction of the coronary microcirculation and metabolism of cardiomyocytes, leading to a transient myocardial stunning. Typically, it presents with acute left ventricular systolic dysfunction that in most cases is completely resolved at short term. Recurrences are rare and it is thought that the long-term prognosis is good. We present here a review of the clinical features, pathophysiology and management of this enigmatic condition.
应激性心肌病是一种在无阻塞性心外膜冠状动脉疾病的情况下，却出现类似急性心肌梗死的综合征，以解释壁运动异常的程度。这种情况在老年女性中通常更为常见，通常由意外的情绪或身体应激情况引发，并伴有心电图异常和心脏生物标志物的轻度升高。其病理生理机制尚不清楚，但据信儿茶酚胺的高循环浓度会导致冠状动脉微循环急性功能障碍和心肌细胞代谢异常，进而导致短暂性心肌顿抑。通常，它表现为急性左心室收缩功能障碍，在大多数情况下短期内可完全恢复。复发很少见，并且认为长期预后良好。我们在此对这种神秘病症的临床特征、病理生理学及治疗进行综述。
