Laboratory of Plant Biotechnology Applied to the Improvement of Cultures, Faculty of Sciences of Sfax, 3038 Sfax, Tunisia.
Chemistry Laboratory of Natural Substances, Faculty of Sciences of Sfax, PB 802, 3018 Sfax, Tunisia.
Carbohydr Polym. 2016 Oct 20;151:511-522. doi: 10.1016/j.carbpol.2016.05.098. Epub 2016 May 28.
A sulfated polysaccharide was successfully isolated from Cymodocea nodosa (CNSP). This is the first report that indicates the chemical composition, structural characterization, functional and antihypertensive properties of this polysaccharide. The CNSP consisted mainly of sulfate (23.17%), total sugars (54.90%), galactose (44.89%), mannose (17.30%), arabinose (12.05%), xylose (9.18%), maltose (1.07%) and uronic acid (11.03%) with low water activity (0.49). CNSP had an XRD pattern that was typical for a semi-crystalline polymer with homogeneous structure. It also displayed an important anti-hypertensive activity (IC50=0.43mgml) with a dose-dependent manner using a synthetic substrate, N-hippuryl-His-Leu hydrate salt (HHL). Overall, the results indicate that CNSP have attractive chemical, functional and biological properties, with a preliminary structural may have a backbone of branched 6-O-sulfated (1→4) galactosidic linkages, which can be considered in the future as alternative additive in various foods, cosmetic and pharmaceutical preparations.
从海菖蒲（Cymodocea nodosa）中成功分离出一种硫酸化多糖（CNSP）。这是首次报道表明该多糖的化学成分、结构特征、功能和降血压特性。CNSP 主要由硫酸根（23.17%）、总糖（54.90%）、半乳糖（44.89%）、甘露糖（17.30%）、阿拉伯糖（12.05%）、木糖（9.18%）、麦芽糖（1.07%）和糖醛酸（11.03%）组成，水活度低（0.49）。CNSP 的 XRD 图谱为典型的半结晶聚合物，具有均匀的结构。它还表现出重要的降血压活性（IC50=0.43mg/ml），对合成底物 N- hippuryl-His-Leu 水盐（HHL）具有剂量依赖性。总体而言，这些结果表明 CNSP 具有有吸引力的化学、功能和生物学特性，其初步结构可能具有支化 6-O-硫酸化（1→4）半乳糖糖苷键的骨架，未来可考虑将其作为各种食品、化妆品和药物制剂的替代添加剂。
