Huber Tyler D, Johnson Brooke R, Zhang Jianjun, Thorson Jon S
Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, United States.
Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY 40536, United States; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, United States.
Curr Opin Biotechnol. 2016 Dec;42:189-197. doi: 10.1016/j.copbio.2016.07.005. Epub 2016 Aug 6.
S-Adenosyl-l-methionine (AdoMet) is an essential enzyme cosubstrate in fundamental biology with an expanding range of biocatalytic and therapeutic applications. In recent years, technologies enabling the synthesis and utilization of novel functional AdoMet surrogates have rapidly advanced. Developments highlighted within this brief review include improved syntheses of AdoMet analogs, unique S-adenosyl-l-methionine isosteres with enhanced stability, and corresponding applications in epigenetics, proteomics and natural product/small molecule diversification ('alkylrandomization').
S-腺苷-L-甲硫氨酸（AdoMet）是基础生物学中一种重要的酶辅底物，其生物催化和治疗应用范围不断扩大。近年来，能够合成和利用新型功能性AdoMet替代物的技术迅速发展。本简要综述重点介绍的进展包括AdoMet类似物合成方法的改进、具有更高稳定性的独特S-腺苷-L-甲硫氨酸电子等排体，以及在表观遗传学、蛋白质组学和天然产物/小分子多样化（“烷基随机化”）方面的相应应用。
