Mitchell K W, Wood C M, Howe J W, Church W H, Smith G T, Spencer S R
Regional Medical Physics Department, Royal Victoria Infirmary, Newcastle upon Tyne.
Br J Ophthalmol. 1989 Jun;73(6):448-56. doi: 10.1136/bjo.73.6.448.
Visual evoked potentials (VEPs) were elicited from 29 patients who had experienced a previous attack of acute primary angle closure glaucoma. The VEPs were shown to be abnormal in at least one of the measures (latency, amplitude, contrast threshold, or slope) in 72.4% of affected eyes, whereas only 41.4% indicated obvious optic nerve damage. It is notable that 48.1% of fellow eyes with no (known) history of acute pressure rise also showed some form of VEP abnormality. The possible pathophysiological mechanisms operating in both affected and fellow eyes are discussed. It is concluded that, despite the presence of possible artefactual influences, the results probably reflect the presence of primary angle closure glaucoma.
对29例既往有急性原发性闭角型青光眼发作史的患者进行了视觉诱发电位（VEP）检测。在72.4%的患眼中，VEP至少在一项指标（潜伏期、波幅、对比度阈值或斜率）上显示异常，而仅有41.4%的患眼显示有明显的视神经损伤。值得注意的是，48.1%无（已知）急性眼压升高病史的对侧眼也表现出某种形式的VEP异常。本文讨论了患眼和对侧眼中可能起作用的病理生理机制。得出的结论是，尽管可能存在人为因素的影响，但这些结果可能反映了原发性闭角型青光眼的存在。
