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美洲地区的基孔肯雅热。对风湿病学家和医疗保健系统的一项挑战。

Chikungunya in the region of the Americas. A challenge for rheumatologists and health care systems.

作者信息

Pineda Carlos, Muñoz-Louis Roberto, Caballero-Uribe Carlo V, Viasus Diego

机构信息

Instituto Nacional de Rehabilitación, Mexico City, Mexico.

Hospital Docente Padre Billini, 10210, Santo Domingo, Dominican Republic.

出版信息

Clin Rheumatol. 2016 Oct;35(10):2381-5. doi: 10.1007/s10067-016-3390-y. Epub 2016 Aug 24.

DOI:10.1007/s10067-016-3390-y
PMID:27553387
Abstract

At the end of 2013, the Pan American Health Organization issued an epidemiological alert due to the detection of the first local cases of Chikungunya in the Americas. By August 2015, autochthonous transmissions were detected in 33 countries and territories of the Americas. Latin America has reported nearly one million cases; only Colombia has issued a report of >200,000 cases during the first 4 months of 2015. In some Latin American and Caribbean countries, Chikungunya becomes a major public health problem. The disease commonly exhibits a self-limited course of arthritis, usually lasting for a few days or that may be prolonged to weeks; however, in 10-60 % of cases, joint pain may become chronic and persist for up to 3-5 years. Human-caused environmental changes, such as climate change, the globalization of international exchange, and disordered urban growth, are some factors that aid in its emergence and dissemination. Outbreaks of Chikungunya comprise a challenge for health care systems and rheumatologists because of the high attack rate on the population and the anticipated development of post-Chikungunya chronic rheumatism. This review emphasizes the rheumatologic clinical manifestations reported in the American continent and highlights the challenges that health care systems face in the absence of an effective vaccine and specific treatment to fight Chikungunya.

摘要

2013年底,泛美卫生组织发布了一项流行病学警报,原因是在美洲检测到首例基孔肯雅热本地病例。截至2015年8月,在美洲的33个国家和地区检测到了本地传播。拉丁美洲报告了近100万例病例;仅哥伦比亚就发布了2015年头4个月超过20万例病例的报告。在一些拉丁美洲和加勒比国家,基孔肯雅热成为一个主要的公共卫生问题。该疾病通常表现为自限性关节炎病程,通常持续数天,也可能延长至数周;然而,在10%至60%的病例中,关节疼痛可能会变为慢性,并持续长达3至5年。人为导致的环境变化,如气候变化、国际交流全球化和无序的城市发展,是有助于其出现和传播的一些因素。基孔肯雅热疫情对医疗系统和风湿病学家构成了挑战,因为其对人群的高发病率以及基孔肯雅热后慢性风湿病的预期发展。本综述强调了美洲大陆报告的风湿病临床表现,并突出了在缺乏有效疫苗和抗基孔肯雅热特异性治疗的情况下医疗系统面临的挑战。

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