Farhad Mollashahi Leila, Honarmand Marieh, Nakhaee Alireza, Mollashahi Ghasem
Department of Oral Medicine, Oral and Dental Disease Research Center, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, IR Iran.
Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.
Int J High Risk Behav Addict. 2016 Feb 8;5(2):e27969. doi: 10.5812/ijhrba.27969. eCollection 2016 Jun.
Smokeless tobacco chewing is one of the known risk factors for oral cancer. It is consumed widely by residents of southeastern Iran.
In this study, salivary free and total sialic acid, and total protein were compared in paan consumers and non-consumers.
In this cross-sectional study, unstimulated saliva of 94 subjects (44 paan consumers and 50 non-consumers) who were referred to the oral medicine department of the dentistry school of Zahedan were collected. Salivary free and total sialic acid, and total protein concentration were measured by standard biochemical methods, and the obtained data were analyzed using SPSS 20 through the non-parametric Mann-Whitney test.
The concentration of salivary free sialic acid (23.21 ± 18.98 mg/L) was significantly increased in paan consumers. The concentration of salivary Total sialic acid (TSA) (39.57 ± 26.58 mg/L) and total protein (0.77 ± 0.81 mg/mL) showed increases in paan consumers, however, the results were not statistically significant.
Salivary free and total sialic acid, and total protein were higher in the paan consumers compared to non-consumers. Due to the carcinogenic effect of smokeless tobacco, measurement of these parameters in saliva may be useful in early detection of oral cancer.
嚼食无烟烟草是口腔癌已知的风险因素之一。伊朗东南部居民广泛嚼食无烟烟草。
本研究比较了嚼食槟榔者和不嚼食槟榔者唾液中游离唾液酸、总唾液酸及总蛋白的水平。
在这项横断面研究中，收集了94名转诊至扎黑丹牙科学院口腔内科的受试者（44名嚼食槟榔者和50名不嚼食槟榔者）的非刺激性唾液。采用标准生化方法测定唾液中游离唾液酸、总唾液酸及总蛋白浓度，并使用SPSS 20通过非参数曼-惠特尼检验对所得数据进行分析。
嚼食槟榔者唾液中游离唾液酸浓度（23.21±18.98mg/L）显著升高。嚼食槟榔者唾液中总唾液酸（TSA）浓度（39.57±26.58mg/L）和总蛋白浓度（0.77±0.81mg/mL）有所升高，但结果无统计学意义。
与不嚼食槟榔者相比，嚼食槟榔者唾液中游离唾液酸、总唾液酸及总蛋白水平更高。鉴于无烟烟草的致癌作用，检测唾液中的这些参数可能有助于口腔癌的早期检测。
