儿童白血病幸存者的智力能力与中枢神经系统照射的关系。
Intellectual abilities among survivors of childhood leukaemia as a function of CNS irradiation.
作者信息
Eiser C
出版信息
Arch Dis Child. 1978 May;53(5):391-5. doi: 10.1136/adc.53.5.391.
Abstract
Twenty-eight children in remission at least 2 years after completing chemotherapy for acute lymphoblastic leukaemia were assessed on standardised psychological tests. It was found that 7 who never had central nervous system (CNS) irradiation and 9 having prophylactic CNS irradiation at least 6 months after diagnosis tended to perform at average or above levels, while those 10 each having prophylactic CNS irradiation (within 2 months of diagnosis) were generally of lower ability. Within the latter group, 3 children showed serious intellectual impairments, while the group as a whole functioned especially poorly on quantitative tasks and those involving speeded performance with abstract material. General language ability was not affected. Practical and theoretical implantation are discussed.
摘要
对28名急性淋巴细胞白血病化疗结束后至少缓解2年的儿童进行了标准化心理测试。结果发现，7名从未接受中枢神经系统（CNS）照射的儿童和9名在诊断后至少6个月接受预防性CNS照射的儿童往往表现为平均水平或以上，而另外10名在诊断后2个月内接受预防性CNS照射的儿童能力普遍较低。在后一组中，3名儿童表现出严重的智力障碍，而这一组整体在定量任务以及涉及抽象材料的快速表现任务上功能特别差。一般语言能力未受影响。文中讨论了实际应用和理论植入。
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