代谢组学在创伤性脑损伤研究中的作用。
Role of Metabolomics in Traumatic Brain Injury Research.
作者信息
Wolahan Stephanie M, Hirt Daniel, Braas Daniel, Glenn Thomas C
机构信息
UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA 90095, USA; Department of Neurosurgery, David Geffen School of Medicine at UCLA, 300 Stein Plaza, Los Angeles, CA 90095-6901, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 570 Westwood Plaza, Los Angeles, CA 90095-1735, USA; UCLA Metabolomics and Proteomics Center, 570 Westwood Plaza, University of California, Los Angeles, Los Angeles, CA 90095, USA.
出版信息
Neurosurg Clin N Am. 2016 Oct;27(4):465-72. doi: 10.1016/j.nec.2016.05.006. Epub 2016 Aug 10.
Abstract
Metabolomics is an important member of the omics community in that it defines which small molecules may be responsible for disease states. This article reviews the essential principles of metabolomics from specimen preparation, chemical analysis, to advanced statistical methods. Metabolomics in traumatic brain injury has so far been underutilized. Future metabolomics-based studies focused on the diagnoses, prognoses, and treatment effects need to be conducted across all types of traumatic brain injury.
摘要
代谢组学是组学领域的重要成员，因为它能确定哪些小分子可能与疾病状态有关。本文综述了代谢组学的基本原理，从样本制备、化学分析到先进的统计方法。迄今为止，代谢组学在创伤性脑损伤中的应用还未得到充分利用。未来需要针对所有类型的创伤性脑损伤开展基于代谢组学的研究，重点关注诊断、预后和治疗效果。
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