Murphy Malia S Q, Tayade Chandrakant, Smith Graeme N
Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada.
Department of Obstetrics and Gynaecology, Kingston General Hospital, 76 Stuart St., Kingston, ON, K7L 2V7, Canada.
Mol Diagn Ther. 2017 Feb;21(1):23-30. doi: 10.1007/s40291-016-0233-0.
Pre-eclampsia (PE) is a common hypertensive disorder of pregnancy with a significant impact on maternal and neonatal mortality and morbidity. While the pathogenesis of PE has been well described, identification of a biomarker(s) with robust predictive utility in identifying women at the highest risk of developing the condition has yet to be identified. In the search for diagnostic markers, those that may be obtained from the circulation are preferred alternatives to those derived from organ tissue samples. Because of their stability in plasma, microRNAs (miRNAs) have been explored as biomarkers in a host of disease states, although there is comparably little literature available on the circulating miRNAome of PE. This article provides a narrative review on the current state of knowledge on miRNAs associated with PE. Literature on circulating miRNAs is presented and the challenges to developing the diagnostic and prognostic utility of miRNAs in this context is discussed.
子痫前期（PE）是一种常见的妊娠高血压疾病，对孕产妇和新生儿的死亡率及发病率有重大影响。虽然PE的发病机制已得到充分描述，但尚未确定一种具有强大预测效用的生物标志物来识别患该病风险最高的女性。在寻找诊断标志物时，可从循环系统中获取的标志物比从器官组织样本中获取的标志物更具优势。由于微小RNA（miRNA）在血浆中具有稳定性，因此在许多疾病状态下都被探索作为生物标志物，尽管关于PE循环miRNA组的文献相对较少。本文对与PE相关的miRNA的当前知识状态进行了叙述性综述。介绍了关于循环miRNA的文献，并讨论了在此背景下开发miRNA诊断和预后效用所面临的挑战。
