Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan ROC.
Division of Electrical and Electronic Engineering, School of Engineering, Manchester Metropolitan University, Manchester M1 5GD, United Kingdom.
Sci Rep. 2016 Sep 21;6:33599. doi: 10.1038/srep33599.
We report a novel and sensitive amperometric sensor for chlorpromazine (CPZ) based on reduced graphene oxide (RGO) and polydopamine (PDA) composite modified glassy carbon electrode. The RGO@PDA composite was prepared by electrochemical reduction of graphene oxide (GO) with PDA. The RGO@PDA composite modified electrode shows an excellent electro-oxidation behavior to CPZ when compared with other modified electrodes such as GO, RGO and GO@PDA. Amperometric i-t method was used for the determination of CPZ. Amperometry result shows that the RGO@PDA composite detects CPZ in a linear range from 0.03 to 967.6 μM. The sensor exhibits a low detection limit of 0.0018 μM with the analytical sensitivity of 3.63 ± 0.3 μAμM(-1 )cm(-2). The RGO@PDA composite shows its high selectivity towards CPZ in the presence of potentially interfering drugs such as metronidazole, phenobarbital, chlorpheniramine maleate, pyridoxine and riboflavin. In addition, the fabricated RGO@PDA modified electrode showed an appropriate recovery towards CPZ in the pharmaceutical tablets.
我们报道了一种基于还原氧化石墨烯（RGO）和聚多巴胺（PDA）复合修饰玻碳电极的新型灵敏电流型传感器，用于检测氯丙嗪（CPZ）。RGO@PDA 复合材料是通过电化学还原氧化石墨烯（GO）与 PDA 制备的。与 GO、RGO 和 GO@PDA 等其他修饰电极相比，RGO@PDA 复合修饰电极对 CPZ 具有优异的电氧化行为。采用安培计时法测定 CPZ。安培计结果表明，RGO@PDA 复合材料在 0.03 至 967.6 μM 的线性范围内检测 CPZ。该传感器具有 0.0018 μM 的低检测限，分析灵敏度为 3.63±0.3 μAμM(-1)cm(-2)。在存在可能干扰药物如甲硝唑、苯巴比妥、马来酸氯苯那敏、吡哆醇和核黄素的情况下，RGO@PDA 复合材料对 CPZ 表现出高选择性。此外，所制备的 RGO@PDA 修饰电极对药物片中的 CPZ 表现出适当的回收率。
