State Key Laboratory of Bioelectronics (Chien-Shiung Wu Lab), School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Nanjing Foreign Language School, Nanjing, 210096, China.
Small. 2016 Dec;12(45):6255-6265. doi: 10.1002/smll.201602526. Epub 2016 Sep 27.
Cancer treatment has a far greater chance of success if the neoplasm is diagnosed before the onset of metastasis to vital organs. Hence, cancer early diagnosis is extremely important and remains a major challenge in modern therapeutics. In this contribution, facile and new method for rapid multimodal tumor bioimaging is reported by using biosynthesized iron complexes and gold nanoclusters via simple introduction of AuCl and Fe ions. The observations demonstrate that the biosynthesized Au nanoclusters may act as fluorescent and computed tomography probes for cancer bioimaging while the iron complexes behave as effective contrast agent for magnetic resonance imaging. The biosynthesized iron complexes and gold nanoclusters are found biocompatible in vitro (MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay) and in vivo for all the vital organs of circulatory and excretory system. These observations raise the possibility that the biosynthesized probes may find applications in future clinical diagnosis for deep seated early neoplasms by multimodal imaging.
如果在转移到重要器官之前就能诊断出肿瘤，癌症的治疗就更有可能成功。因此，癌症的早期诊断极其重要，仍然是现代治疗学的一个主要挑战。在本研究中，通过简单引入 AuCl 和 Fe 离子，报道了一种使用生物合成的铁配合物和金纳米簇进行快速多模态肿瘤生物成像的简便新方法。观察结果表明，生物合成的 Au 纳米簇可用作荧光和计算机断层扫描探针进行癌症生物成像，而铁配合物则可用作磁共振成像的有效对比剂。生物合成的铁配合物和金纳米簇在体外（MTT（3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴盐）测定）和循环和排泄系统的所有重要器官中均表现出良好的生物相容性。这些观察结果表明，这些生物合成的探针可能有希望通过多模态成像应用于未来深部早期肿瘤的临床诊断。
