Alqurashi Randah M, Galante Laura A, Rowland Ian R, Spencer Jeremy Pe, Commane Daniel M
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, United Kingdom.
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, United Kingdom
Am J Clin Nutr. 2016 Nov;104(5):1227-1235. doi: 10.3945/ajcn.115.128728. Epub 2016 Sep 28.
Açai (Euterpe oleracea) is a polyphenol-rich fruit marketed as beneficial for health. Experimental data showing improvements in health markers arising from açai consumption in humans is limited.
The objective of the present study was to investigate the effect of açai consumption on acute changes in vascular function and on other disease risk markers, including postprandial plasma insulin, glucose, and oxidative stress.
Twenty-three healthy male volunteers, aged 30-65 y and with a body mass index (in kg/m) of 25-30, completed a randomized, controlled, high-fat challenge, double-blind, crossover, acute dietary intervention trial. The volunteers consumed either an açai-based smoothie (AS) or a macronutrient-matched control smoothie (PS) together with a high-fat breakfast meal challenge. The primary endpoint was the assessment of endothelial function in the brachial artery by flow-mediated dilatation (FMD).
The acute consumption of an AS containing 694 mg total phenolics improved vascular function, with postprandial increases in FMD from baseline of 1.4% at 2 h compared with 0.4% after consumption of the PS (P = 0.001) and increases at 6 h of 0.8% for the AS compared with -0.3% for the PS (P < 0.001). There was also a significantly lower incremental area under the curve (iAUC) for total peroxide oxidative status after açai consumption relative to the control. No significant changes were observed in blood pressure, heart rate, or postprandial glucose response. However, the first postprandial insulin peak (after breakfast) and the iAUC for insulin were elevated for the AS relative to the PS.
In this acute study in overweight men, açai consumption was associated with improvements in vascular function, which may lower the risk of a cardiovascular event. Future intervention studies, perhaps with a chronic design, in wider populations and with other biomarkers of disease risk are needed to fully elucidate the benefits of açai to health. This trial was registered at clinicaltrials.gov as NCT02292329.
阿萨伊果（Euterpe oleracea）是一种富含多酚的水果，作为对健康有益的产品进行销售。关于人类食用阿萨伊果后健康指标得到改善的实验数据有限。
本研究的目的是调查食用阿萨伊果对血管功能急性变化以及其他疾病风险指标的影响，包括餐后血浆胰岛素、葡萄糖和氧化应激。
23名年龄在30 - 65岁、体重指数（kg/m²）为25 - 30的健康男性志愿者完成了一项随机、对照、高脂肪挑战、双盲、交叉、急性饮食干预试验。志愿者们在进行高脂肪早餐挑战时，分别饮用了以阿萨伊果为基础的奶昔（AS）或宏量营养素匹配的对照奶昔（PS）。主要终点是通过血流介导的血管舒张（FMD）评估肱动脉的内皮功能。
急性食用含有694毫克总酚类物质的AS可改善血管功能，餐后2小时FMD相对于基线增加1.4%，而食用PS后为0.4%（P = 0.001）；AS在6小时时增加0.8%，而PS为 - 0.3%（P < 0.001）。与对照组相比，食用阿萨伊果后总过氧化物氧化状态的曲线下增量面积（iAUC）也显著更低。血压、心率或餐后血糖反应未观察到显著变化。然而，相对于PS组，AS组餐后第一个胰岛素峰值（早餐后）和胰岛素的iAUC升高。
在这项针对超重男性的急性研究中，食用阿萨伊果与血管功能改善相关，这可能降低心血管事件的风险。未来需要在更广泛的人群中进行干预研究，或许采用长期设计，并纳入其他疾病风险生物标志物，以充分阐明阿萨伊果对健康的益处。该试验已在clinicaltrials.gov上注册，注册号为NCT02292329。
