Chu Derrick M, Meyer Kristen M, Prince Amanda L, Aagaard Kjersti M
a Department of Obstetrics and Gynecology , Baylor College of Medicine , Houston , TX.
b Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine , Houston , TX.
Gut Microbes. 2016 Nov;7(6):459-470. doi: 10.1080/19490976.2016.1241357. Epub 2016 Sep 29.
Evidence supporting the Developmental Origins of Health and Disease Hypothesis indicates that maternal nutrition in pregnancy has a significant impact on offspring disease risk later in life, likely by modulating developmental processes in utero. Gut microbiota have recently been explored as a potential mediating factor, as dietary components strongly influence microbiota abundance, function and its impact on host physiology. A growing body of evidence has additionally indicated that the intrauterine environment is not sterile as once presumed, indicating that maternal-fetal transmission of microbiota may occur during pregnancy. In this article, we will review the body of literature that supports this emerging hypothesis, as well as highlight the work in relevant animal models demonstrating associations with maternal gestational nutrition and the offspring gut microbiome that may influence offspring physiology and susceptibility to disease.
支持健康与疾病发育起源假说的证据表明，孕期母亲营养对后代成年后患疾病的风险有重大影响，这可能是通过调节子宫内的发育过程实现的。肠道微生物群最近被视为一个潜在的中介因素，因为饮食成分会强烈影响微生物群的丰度、功能及其对宿主生理的影响。越来越多的证据还表明，子宫内环境并非如人们曾经认为的那样无菌，这表明孕期可能发生微生物群的母婴传播。在本文中，我们将回顾支持这一新兴假说的文献，并重点介绍相关动物模型中的研究工作，这些研究表明母亲孕期营养与后代肠道微生物群之间存在关联，而这可能会影响后代的生理机能和疾病易感性。
