Palmieri Valentina, Papi Massimiliano, Conti Claudio, Ciasca Gabriele, Maulucci Giuseppe, De Spirito Marco
a Physics Institute , Catholic University of Sacred Hearth , Rome , Italy.
b Institute for Complex Systems , National Research Council (ISC-CNR) , Rome , Italy.
Expert Rev Med Devices. 2016 Nov;13(11):1013-1019. doi: 10.1080/17434440.2016.1245612.
The clinical challenge that research on antibacterial coatings faces nowadays is the need of reduction of resistant bacterial infections, major source of implant rejection and repeated surgery. In order to avoid microorganisms attachment and biofilm formation, coating materials on medical devices have been developed with shortcomings represented by short-term durability and induction of new mechanisms of bacterial resistance. Graphene-based films and hydrogel could represent the next generation protective coatings due to their excellent mechanical, chemical and thermal properties, high nanoparticle adsorption and antibacterial action. Areas covered: In this short commentary, we will report the recent developments of graphene oxide based coatings. Graphene oxide is a water-soluble derivative of graphene that allows high drug loading and miscibility with polymers, making it mouldable in any desired shape. Recent applications in wound healing and tissue engineering will be discussed as well as critical issues prior to clinical use of graphene oxide coatings. Expert commentary: The current evidence is insufficient to establish the efficacy of Graphene Oxide against bacteria and the durability of coatings. Further studies should clarify how to control Graphene Oxide antibacterial mechanism.
目前抗菌涂层研究面临的临床挑战是需要减少耐药细菌感染，这是植入物排斥和重复手术的主要根源。为了避免微生物附着和生物膜形成，已开发出医疗设备上的涂层材料，但存在短期耐久性和诱导细菌耐药新机制等缺点。基于石墨烯的薄膜和水凝胶因其优异的机械、化学和热性能、高纳米颗粒吸附性和抗菌作用，可能代表下一代防护涂层。涵盖领域：在这篇简短评论中，我们将报告基于氧化石墨烯涂层的最新进展。氧化石墨烯是石墨烯的水溶性衍生物，具有高载药量且能与聚合物混溶，使其可塑成任何所需形状。还将讨论其在伤口愈合和组织工程中的最新应用以及氧化石墨烯涂层临床应用前的关键问题。专家评论：目前的证据不足以确定氧化石墨烯对细菌的疗效和涂层的耐久性。进一步的研究应阐明如何控制氧化石墨烯的抗菌机制。
