Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Adv Exp Med Biol. 2020;1282:21-35. doi: 10.1007/5584_2019_434.
The clinical challenge on surface engineering of medical devices to prevent microorganisms adhesion and biofilm formation, has become an essential aspect for medical implants. Antibacterial properties of Graphene Oxide (GO) have been demonstrated across a broad spectrum of bacteria, and the different mechanisms of action with which this nanomaterial interacts with the microbial surface have been elucidated in detail. Innovative protective coatings based on graphene film and hydrogel could represent an innovative solution for the prevention of nosocomial pathogens colonization on implantable device. This brief review mainly focuses on the applications of graphene in nanomedicine with a particular deepening on the antibacterial properties of GO and GO-based nanomaterials. In order to evaluate the possible future applications of GO as an anti-biofilm coating material for medical devices, studies on the ability of graphene coated surface to prevent microbial adhesion are also discussed. A concise review on in vitro toxicity and in vivo safety is also presented.
医疗器械表面工程以防止微生物黏附和生物膜形成的临床挑战，已成为医疗植入物的一个重要方面。氧化石墨烯（GO）的抗菌性能已在广谱细菌中得到证实，并且已经详细阐明了这种纳米材料与微生物表面相互作用的不同作用机制。基于石墨烯薄膜和水凝胶的创新保护涂层可能代表了一种预防植入式设备中医院病原体定植的创新解决方案。这篇简要综述主要关注了石墨烯在纳米医学中的应用，特别深入探讨了 GO 及其基于 GO 的纳米材料的抗菌特性。为了评估 GO 作为医疗器械抗生物膜涂层材料的可能未来应用，还讨论了石墨烯涂覆表面防止微生物黏附的能力。还简要介绍了体外毒性和体内安全性的研究。
