自主细菌纳米游动器靶向癌症。
Autonomous bacterial nanoswimmers target cancer.
作者信息
Zoaby Nour, Shainsky-Roitman Janna, Badarneh Samah, Abumanhal Hanan, Leshansky Alex, Yaron Sima, Schroeder Avi
机构信息
Department of Chemical Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
Department of Biotechnology and Food Engineering, Technion - Israel Institute of Technology, Haifa 32000, Israel.
出版信息
J Control Release. 2017 Jul 10;257:68-75. doi: 10.1016/j.jconrel.2016.10.006. Epub 2016 Oct 12.
Injectable drug delivery systems that autonomously detect, propel towards, and ultimately treat the cancerous tissue, are the future of targeted medicine. Here, we developed a drug delivery system that swims autonomously towards cancer cells, where it releases a therapeutic cargo. This platform is based on viable bacteria, loaded with nanoparticles that contain the chemotherapeutic-antibiotic drug doxorubicin. The bacteria ferry across media and invade the cancer cells, increasing their velocity in the presence of nutrients that are present within the tumor microenvironment. Inside the cancer cells, doxorubicin is released from the nanoparticles, destroying the bacterial swimmer (antibiotic activity) and executing the therapeutic activity against the cancer cells (chemotherapeutic activity). This mode of delivery, where both the carrier and the cancer cell are destroyed, supports implementing nanoswimmers in drug delivery (Fig. 1).
能够自主检测、向癌组织推进并最终治疗癌组织的可注射药物递送系统，是靶向医学的未来。在此，我们开发了一种药物递送系统，它能自主游向癌细胞，并在癌细胞处释放治疗性药物。该平台基于活细菌，装载有包含化疗抗生素药物阿霉素的纳米颗粒。细菌穿梭于介质中并侵入癌细胞，在肿瘤微环境中存在的营养物质的作用下加快游动速度。在癌细胞内，阿霉素从纳米颗粒中释放出来，破坏细菌游动体（抗生素活性）并对癌细胞执行治疗活性（化疗活性）。这种载体和癌细胞都被破坏的递送模式，支持在药物递送中应用纳米游动体（图1）。
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