食物过敏口服免疫疗法的进展：走向耐受性。
Advances in food allergy oral immunotherapy: toward tolerance.
作者信息
Hussey Freeland Deborah M, Fan-Minogue Hua, Spergel Jonathan M, Chatila Talal A, Nadeau Kari C
机构信息
Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University School of Medicine, Stanford, CA, USA.
Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
出版信息
Curr Opin Immunol. 2016 Oct;42:119-123. doi: 10.1016/j.coi.2016.08.002. Epub 2016 Oct 13.
The incidence of food allergy, a disease characterized by adverse immune responses that can render common foods life-threatening, is rising. Yet our current standard of care is simply avoidance of allergenic foods and administration of emergency medications upon accidental exposure. Significant advances have been made in food allergy oral immunotherapy, which is emerging as a potential preventive and curative treatment for this disease. The fundamental strategy of oral immunotherapy is to mitigate adverse immune responses to allergenic food proteins through repeated exposure; reduced reactivity to food allergens (desensitization) often results, but the establishment of sustained immune unresponsiveness or of permanent resolution (tolerance) is not certain. This review examines exciting recent developments in oral immunotherapy for food allergy.
食物过敏是一种以不良免疫反应为特征的疾病，常见食物也可能会危及生命，其发病率正在上升。然而，我们目前的治疗标准仅仅是避免食用致敏食物，并在意外接触后使用急救药物。食物过敏口服免疫疗法已经取得了重大进展，正在成为这种疾病一种潜在的预防和治疗方法。口服免疫疗法的基本策略是通过反复接触来减轻对致敏食物蛋白的不良免疫反应；通常会导致对食物过敏原的反应性降低（脱敏），但能否建立持续的免疫无反应性或实现永久性缓解（耐受）尚不确定。这篇综述探讨了食物过敏口服免疫疗法最近令人兴奋的进展。
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