• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

赭曲霉花青苷，一种赭曲霉毒素-麦角固醇异二聚体，可抑制16D-1产生白细胞介素-6和一氧化氮。

Ochrasperfloroid, an ochratoxin-ergosteroid heterodimer with inhibition of IL-6 and NO production from 16D-1.

作者信息

Gu Bin-Bin, Jiao Fu-Rong, Wu Wei, Liu Lei, Jiao Wei-Hua, Sun Fan, Wang Shu-Ping, Yang Fan, Lin Hou-Wen

机构信息

Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Renji Hospital School of Medicine, Shanghai Jiao Tong University Shanghai 200127 China

出版信息

RSC Adv. 2019 Mar 4;9(13):7251-7256. doi: 10.1039/c8ra10539a. eCollection 2019 Mar 1.

DOI:10.1039/c8ra10539a
PMID:35519937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9061062/
Abstract

A novel ochratoxin-ergosteroid heterodimer, ochrasperfloroid (1), together with a known mycotoxin, ochratoxin A (2), were isolated from the sponge-derived fungus 16D-1. The structure of 1 was determined on the basis of 1D/2D NMR, HRESIMS/MS, and LC-UV/MS analysis of its alkaline hydrolyzates, quantum-chemical C NMR calculation, and comparison with literature data. Of note, the ergosteroid embedded in 1 is also a new structure. Ochrasperfloroid (1) showed potent inhibitory activity towards IL-6 production in lipopolysaccharide (LPS)-induced THP-1 cell line, with an IC value of 2.02 μM, and NO production in LPS-activated RAW264.7 macrophages, with an IC value of 1.11 μM.

摘要

从海绵来源的真菌16D-1中分离出一种新型的赭曲霉毒素-麦角甾醇异二聚体——赭曲asperfloroid（1），以及一种已知的霉菌毒素——赭曲霉毒素A（2）。通过对其碱性水解产物的一维/二维核磁共振、高分辨电喷雾电离质谱/质谱和液相色谱-紫外/质谱分析、量子化学碳核磁共振计算以及与文献数据的比较，确定了1的结构。值得注意的是，嵌入在1中的麦角甾醇也是一种新结构。赭曲asperfloroid（1）对脂多糖（LPS）诱导的THP-1细胞系中白细胞介素-6的产生显示出强效抑制活性，IC值为2.02 μM，对LPS激活的RAW264.7巨噬细胞中一氧化氮的产生也有抑制作用，IC值为1.11 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e380/9061062/d8b09351d3b3/c8ra10539a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e380/9061062/d8b09351d3b3/c8ra10539a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e380/9061062/d8b09351d3b3/c8ra10539a-f1.jpg

相似文献

1
Ochrasperfloroid, an ochratoxin-ergosteroid heterodimer with inhibition of IL-6 and NO production from 16D-1.赭曲霉花青苷，一种赭曲霉毒素-麦角固醇异二聚体，可抑制16D-1产生白细胞介素-6和一氧化氮。
RSC Adv. 2019 Mar 4;9(13):7251-7256. doi: 10.1039/c8ra10539a. eCollection 2019 Mar 1.
2
Asperflotone, an 8(14→15)- abeo-Ergostane from the Sponge-Derived Fungus Aspergillus flocculosus 16D-1.asperflotone，一种 8(14→15)-abeo-Ergostane，来源于海绵来源真菌灰绿曲霉 16D-1。
J Org Chem. 2019 Jan 4;84(1):300-306. doi: 10.1021/acs.joc.8b02679. Epub 2018 Dec 21.
3
Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca.从海洋海绵 Phakellia fusca 中分离出的真菌 Aspergillus flocculosus 16D-1 中具有抑制 IL-6 表达的 Preussins。
J Nat Prod. 2018 Oct 26;81(10):2275-2281. doi: 10.1021/acs.jnatprod.8b00662. Epub 2018 Oct 15.
4
Aspersecosteroids A and B, Two 11(9 → 10)- abeo-5,10-Secosteroids with a Dioxatetraheterocyclic Ring System from Aspergillus flocculosus 16D-1.灰绿青霉 16D-1 中两种具有二氧杂六元杂环系统的 11(9→10)-abeo-5,10-裂环甾体：aspersecosteroids A 和 B
Org Lett. 2018 Dec 21;20(24):7957-7960. doi: 10.1021/acs.orglett.8b03530. Epub 2018 Dec 4.
5
New Anti-inflammatory Cyclopeptides From a Sponge-Derived Fungus .源自海绵共生真菌的新型抗炎环肽
Front Chem. 2018 Jun 14;6:226. doi: 10.3389/fchem.2018.00226. eCollection 2018.
6
Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated 16D-1.曲霉弗洛凯他醇A和B，前两个具有重排A环和D环的麦角甾烷：源自海绵共生菌16D-1。
J Org Chem. 2021 Aug 20;86(16):10954-10961. doi: 10.1021/acs.joc.0c02049. Epub 2020 Oct 14.
7
Trienic α-pyrone and ochratoxin derivatives from a sponge-derived fungus Aspergillus ochraceopetaliformis.来自海绵源真菌Petaliformis曲霉的三环α-吡喃酮和赭曲霉毒素衍生物。
Nat Prod Res. 2018 Aug;32(15):1791-1797. doi: 10.1080/14786419.2017.1402325. Epub 2017 Nov 13.
8
Suppression of RANKL-Induced Osteoclastogenesis by the Metabolites from the Marine Fungus Aspergillus flocculosus Isolated from a Sponge Stylissa sp.海绵来源真菌拟青霉代谢产物抑制 RANKL 诱导的破骨细胞生成
Mar Drugs. 2018 Jan 5;16(1):14. doi: 10.3390/md16010014.
9
New Ophiobolin Derivatives from the Marine Fungus and Their Cytotoxicities against Cancer Cells.海洋真菌中新海鞘素衍生物及其对癌细胞的细胞毒性。
Mar Drugs. 2019 Jun 11;17(6):346. doi: 10.3390/md17060346.
10
Asteltoxins with Antiviral Activities from the Marine Sponge-Derived Fungus Aspergillus sp. SCSIO XWS02F40.从海洋海绵衍生真菌曲霉属SCSIO XWS02F40中分离得到的具有抗病毒活性的曲霉毒素。
Molecules. 2015 Dec 26;21(1):E34. doi: 10.3390/molecules21010034.

引用本文的文献

1
Structure and Biological Activity of Ergostane-Type Steroids from Fungi.真菌麦角甾烷型甾体的结构与生物活性。
Molecules. 2022 Mar 24;27(7):2103. doi: 10.3390/molecules27072103.
2
A Review: Halogenated Compounds from Marine Fungi.海洋真菌中的卤代化合物综述。
Molecules. 2021 Jan 16;26(2):458. doi: 10.3390/molecules26020458.

本文引用的文献

1
Aspersecosteroids A and B, Two 11(9 → 10)- abeo-5,10-Secosteroids with a Dioxatetraheterocyclic Ring System from Aspergillus flocculosus 16D-1.灰绿青霉 16D-1 中两种具有二氧杂六元杂环系统的 11(9→10)-abeo-5,10-裂环甾体：aspersecosteroids A 和 B
Org Lett. 2018 Dec 21;20(24):7957-7960. doi: 10.1021/acs.orglett.8b03530. Epub 2018 Dec 4.
2
Preussins with Inhibition of IL-6 Expression from Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine Sponge Phakellia fusca.从海洋海绵 Phakellia fusca 中分离出的真菌 Aspergillus flocculosus 16D-1 中具有抑制 IL-6 表达的 Preussins。
J Nat Prod. 2018 Oct 26;81(10):2275-2281. doi: 10.1021/acs.jnatprod.8b00662. Epub 2018 Oct 15.
3
Nitric oxide promotes cancer cell dedifferentiation by disrupting an Oct4:caveolin-1 complex: A new regulatory mechanism for cancer stem cell formation.
一氧化氮通过破坏 Oct4： caveolin-1 复合物促进癌细胞去分化：癌症干细胞形成的新调控机制。
J Biol Chem. 2018 Aug 31;293(35):13534-13552. doi: 10.1074/jbc.RA117.000287. Epub 2018 Jul 9.
4
IL-6 family cytokines: Key inflammatory mediators as biomarkers and potential therapeutic targets.白细胞介素-6家族细胞因子：作为生物标志物和潜在治疗靶点的关键炎症介质
Cytokine Growth Factor Rev. 2018 Jun;41:10-17. doi: 10.1016/j.cytogfr.2018.04.004. Epub 2018 Apr 18.
5
Targeting the IL-6/JAK/STAT3 signalling axis in cancer.针对癌症中的 IL-6/JAK/STAT3 信号通路。
Nat Rev Clin Oncol. 2018 Apr;15(4):234-248. doi: 10.1038/nrclinonc.2018.8. Epub 2018 Feb 6.
6
Marine natural products.海洋天然产物。
Nat Prod Rep. 2018 Jan 16;35(1):8-53. doi: 10.1039/c7np00052a.
7
Marine natural products.海洋天然产物。
Nat Prod Rep. 2017 Mar 17;34(3):235-294. doi: 10.1039/c6np00124f.
8
Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp.亮海绵素A和纳胺J，来自海洋海绵亮海绵属的甘油醚脂质和咪唑生物碱
J Asian Nat Prod Res. 2017 Jul;19(7):691-696. doi: 10.1080/10286020.2016.1240171. Epub 2016 Oct 19.
9
Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression.一氧化氮合酶-2衍生的一氧化氮驱动乳腺癌进展的多种途径。
Antioxid Redox Signal. 2017 Jun 20;26(18):1044-1058. doi: 10.1089/ars.2016.6813. Epub 2016 Sep 7.
10
Marine natural products.海洋天然产物。
Nat Prod Rep. 2016 Mar;33(3):382-431. doi: 10.1039/c5np00156k. Epub 2016 Feb 3.