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2016年从黎巴嫩鸡群中分离出的首例H5N1禽流感病毒的全基因组序列

Complete Genome Sequence of the First H5N1 Avian Influenza Virus Isolated from Chickens in Lebanon in 2016.

作者信息

Ibrahim Elias, Sirawan Abeer, El-Bazzal Bassel, El Hage Jeanne, Abi Said Mounir, Zaraket Hassan, Kandeil Ahmed, Ali Mohamed A, Kayali Ghazi

机构信息

Ministry of Agriculture, Beirut, Lebanon.

Lebanese Agricultural Research Institute, Animal Health Laboratory, Fanar, Lebanon.

出版信息

Genome Announc. 2016 Oct 20;4(5):e01062-16. doi: 10.1128/genomeA.01062-16.

DOI:10.1128/genomeA.01062-16
PMID:27795243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5073251/
Abstract

We generated the full genome of a highly pathogenic H5N1 avian influenza virus that caused an outbreak on a chicken farm in Lebnaon in April 2016. Analysis revealed that the virus belonged to clade 2.3.2.1c that recently caused outbreaks in West Africa and the United Arab Emirates.

摘要

我们获得了一株高致病性H5N1禽流感病毒的全基因组，该病毒于2016年4月在黎巴嫩的一个养鸡场引发了疫情。分析显示，该病毒属于2.3.2.1c分支，此分支最近在西非和阿拉伯联合酋长国引发了疫情。

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本文引用的文献

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Outbreaks of highly pathogenic avian influenza H5N1 clade 2.3.2.1c in hunting falcons and kept wild birds in Dubai implicate intercontinental virus spread.在迪拜，猎鹰和人工饲养的野生鸟类中出现的高致病性H5N1 2.3.2.1c分支禽流感疫情表明病毒已在洲际间传播。
J Gen Virol. 2015 Nov;96(11):3212-3222. doi: 10.1099/jgv.0.000274.
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Nomenclature updates resulting from the evolution of avian influenza A(H5) virus clades 2.1.3.2a, 2.2.1, and 2.3.4 during 2013-2014.2013 - 2014年期间甲型禽流感病毒2.1.3.2a、2.2.1和2.3.4进化分支导致的命名更新。
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A single residue substitution in the receptor-binding domain of H5N1 hemagglutinin is critical for packaging into pseudotyped lentiviral particles.H5N1 血凝素受体结合域中的单个残基取代对于包装到假型慢病毒颗粒中至关重要。
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Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host.鉴定 HA 和 PB2 中对 H5N1 禽流感病毒在哺乳动物宿主中传播至关重要的氨基酸。
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