黑磷纳米片作为癌症治疗与诊断一体化的稳健递药平台。
Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics.
机构信息
Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China.
School of Life Sciences, Tsinghua University, Beijing, 100084, China.
出版信息
Adv Mater. 2017 Jan;29(1). doi: 10.1002/adma.201603276. Epub 2016 Oct 31.
Abstract
2D black phosphorus (BP) nanomaterials are presented as a delivery platform. The endocytosis pathways and biological activities of PEGylated BP nanosheets in cancer cells are revealed for the first time. Finally, a triple-response combined therapy strategy is achieved by PEGylated BP nanosheets, showing a promising and enhanced antitumor effect.
摘要
二维黑磷（BP）纳米材料被提出作为一种递送平台。首次揭示了聚乙二醇化 BP 纳米片在癌细胞中的内吞途径和生物活性。最后，通过聚乙二醇化 BP 纳米片实现了三重响应联合治疗策略，显示出有前途和增强的抗肿瘤效果。
相似文献
1
Black Phosphorus Nanosheets as a Robust Delivery Platform for Cancer Theranostics.黑磷纳米片作为癌症治疗与诊断一体化的稳健递药平台。
Adv Mater. 2017 Jan;29(1). doi: 10.1002/adma.201603276. Epub 2016 Oct 31.
2
Aggregation-Induced Emission Luminogens Married to 2D Black Phosphorus Nanosheets for Highly Efficient Multimodal Theranostics.聚集诱导发光材料嫁接到二维黑磷纳米片中用于高效的多模式诊疗一体。
Adv Mater. 2020 Sep;32(37):e2003382. doi: 10.1002/adma.202003382. Epub 2020 Aug 6.
3
Graphene-like Metal-Free 2D Nanosheets for Cancer Imaging and Theranostics.用于癌症成像和治疗的类石墨烯无金属二维纳米片。
Trends Biotechnol. 2018 Nov;36(11):1145-1156. doi: 10.1016/j.tibtech.2018.05.012. Epub 2018 Jun 26.
4
2D Nanomaterials for Cancer Theranostic Applications.二维纳米材料在癌症治疗中的应用。
Adv Mater. 2020 Apr;32(13):e1902333. doi: 10.1002/adma.201902333. Epub 2019 Jul 28.
5
Calcium-cation-doped polydopamine-modified 2D black phosphorus nanosheets as a robust platform for sensitive and specific biomolecule sensing.钙-阳离子掺杂聚多巴胺修饰的二维黑磷纳米片作为灵敏和特异生物分子传感的坚固平台。
Anal Chim Acta. 2020 Jul 18;1121:1-10. doi: 10.1016/j.aca.2020.04.072. Epub 2020 Apr 30.
6
Black Phosphorus Nanosheet-Based Drug Delivery System for Synergistic Photodynamic/Photothermal/Chemotherapy of Cancer.基于黑磷纳米片的药物传递系统用于癌症的协同光动力/光热/化学治疗。
Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201603864. Epub 2016 Nov 24.
7
2D Hetero-Nanoconstructs of Black Phosphorus for Breast Cancer Theragnosis: Technological Advancements.二维黑磷杂化纳米结构用于乳腺癌诊疗一体化：技术进展
Biosensors (Basel). 2022 Nov 11;12(11):1009. doi: 10.3390/bios12111009.
8
Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy.用于肿瘤微环境调控和抗癌治疗的二维纳米材料。
Adv Drug Deliv Rev. 2022 Aug;187:114360. doi: 10.1016/j.addr.2022.114360. Epub 2022 May 28.
9
Biodegradable Black Phosphorus-based Nanomaterials in Biomedicine: Theranostic Applications.可生物降解的基于黑磷的纳米材料在生物医学中的治疗诊断应用。
Curr Med Chem. 2019;26(10):1788-1805. doi: 10.2174/0929867324666170920152529.
10
A Highly Effective π-π Stacking Strategy To Modify Black Phosphorus with Aromatic Molecules for Cancer Theranostics.一种高效的π-π堆积策略，用于用芳香分子修饰黑磷用于癌症治疗诊断。
ACS Appl Mater Interfaces. 2019 Mar 13;11(10):9860-9871. doi: 10.1021/acsami.9b00374. Epub 2019 Feb 27.
引用本文的文献
1
NIR/pH-responsive arginine-ε-polylysine/black phosphorus nanocomposites for synergistic therapy of bacterial infections.用于细菌感染协同治疗的近红外/ pH响应性精氨酸-ε-聚赖氨酸/黑磷纳米复合材料
Mater Today Bio. 2025 Aug 28;34:102235. doi: 10.1016/j.mtbio.2025.102235. eCollection 2025 Oct.
2
Global research trend of graphene application in breast cancer: a bibliometric analysis.石墨烯在乳腺癌中应用的全球研究趋势：一项文献计量分析
Int J Surg. 2025 Sep 1;111(9):6305-6317. doi: 10.1097/JS9.0000000000002722. Epub 2025 Jun 25.
3
Multifunctional Nanomaterials: Recent Advancements in Cancer Therapeutics and Vaccines.多功能纳米材料：癌症治疗与疫苗的最新进展
Indian J Microbiol. 2025 Mar;65(1):51-68. doi: 10.1007/s12088-024-01274-x. Epub 2024 May 26.
4
Massage-Mimicking Nanosheets Mechanically Reorganize Inter-organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease.模仿按摩的纳米片通过机械方式重组细胞器间接触以恢复帕金森病中的线粒体功能
Adv Sci (Weinh). 2025 May;12(20):e2413376. doi: 10.1002/advs.202413376. Epub 2025 Apr 13.
5
Photothermally Responsive Hydrogel Releases Basic Fibroblast Growth Factor to Promote the Healing of Infected Wounds.光热响应水凝胶释放碱性成纤维细胞生长因子以促进感染伤口愈合。
Biomater Res. 2025 Mar 4;29:0156. doi: 10.34133/bmr.0156. eCollection 2025.
6
Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review.使用先进功能纳米药物调控癌症相关成纤维细胞以增强癌症免疫治疗：最新综述
J Nanobiotechnology. 2025 Mar 4;23(1):166. doi: 10.1186/s12951-025-03217-0.
7
Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer.纳米脂质体介导的肝癌光热治疗的临床前进展
Lipids Health Dis. 2025 Jan 31;24(1):31. doi: 10.1186/s12944-024-02429-x.
8
Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression.治疗性黑磷纳米片引发中性粒细胞反应以增强肿瘤抑制作用。
Adv Sci (Weinh). 2025 Apr;12(14):e2414779. doi: 10.1002/advs.202414779. Epub 2025 Jan 22.
9
Nanocapsuled Neutrophil Extracellular Trap Scavenger Combating Chronic Infectious Bone Destruction Diseases.纳米胶囊包裹的中性粒细胞胞外诱捕网清除剂对抗慢性感染性骨破坏疾病
Adv Sci (Weinh). 2025 Mar;12(10):e2411274. doi: 10.1002/advs.202411274. Epub 2025 Jan 17.
10
Two-Dimensional Phototransistors with van der Waals Superstructure Contacts for High-Performance Photosensing.具有范德华超结构接触的二维光电晶体管用于高性能光传感
ACS Appl Mater Interfaces. 2025 Jan 29;17(4):6521-6529. doi: 10.1021/acsami.4c16883. Epub 2025 Jan 13.
本文引用的文献
1
Graphene and the immune system: Challenges and potentiality.石墨烯与免疫系统：挑战与潜能。
Adv Drug Deliv Rev. 2016 Oct 1;105(Pt B):163-175. doi: 10.1016/j.addr.2016.05.014. Epub 2016 May 25.
2
Covalent functionalization and passivation of exfoliated black phosphorus via aryl diazonium chemistry.通过芳基重氮化学对剥离的黑磷进行共价功能化和钝化。
Nat Chem. 2016 Jun;8(6):597-602. doi: 10.1038/nchem.2505. Epub 2016 May 2.
3
Biomedical Uses for 2D Materials Beyond Graphene: Current Advances and Challenges Ahead.二维材料在石墨烯之外的生物医学用途：当前进展和未来挑战。
Adv Mater. 2016 Aug;28(29):6052-74. doi: 10.1002/adma.201506306. Epub 2016 Apr 23.
4
Solution-Processed Two-Dimensional Metal Dichalcogenide-Based Nanomaterials for Energy Storage and Conversion.溶液处理的二维金属二卤族化物基纳米材料用于能量存储和转换。
Adv Mater. 2016 Aug;28(29):6167-96. doi: 10.1002/adma.201504833. Epub 2016 Apr 13.
5
One-pot solventless preparation of PEGylated black phosphorus nanoparticles for photoacoustic imaging and photothermal therapy of cancer.一锅无溶剂法制备聚乙二醇化黑磷纳米粒子用于癌症的光声成像和光热治疗。
Biomaterials. 2016 Jun;91:81-89. doi: 10.1016/j.biomaterials.2016.03.022. Epub 2016 Mar 17.
6
Polydopamine-Based Surface Modification of Novel Nanoparticle-Aptamer Bioconjugates for In Vivo Breast Cancer Targeting and Enhanced Therapeutic Effects.基于聚多巴胺的新型纳米颗粒-适配体生物共轭物的表面修饰用于体内乳腺癌靶向及增强治疗效果
Theranostics. 2016 Feb 11;6(4):470-84. doi: 10.7150/thno.14184. eCollection 2016.
7
Molecular and Genomic Impact of Large and Small Lateral Dimension Graphene Oxide Sheets on Human Immune Cells from Healthy Donors.大、小横向尺寸氧化石墨烯片对健康供体人类免疫细胞的分子和基因组影响。
Adv Healthc Mater. 2016 Jan 21;5(2):276-87. doi: 10.1002/adhm.201500606. Epub 2015 Dec 20.
8
Quantum emission from hexagonal boron nitride monolayers.六方氮化硼单层中的量子发射。
Nat Nanotechnol. 2016 Jan;11(1):37-41. doi: 10.1038/nnano.2015.242. Epub 2015 Oct 26.
9
Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects.二维纳米材料在生物医学中的应用：新兴趋势与未来展望。
Adv Mater. 2015 Dec 2;27(45):7261-84. doi: 10.1002/adma.201502422. Epub 2015 Oct 13.
10
Ultrathin Two-Dimensional Nanomaterials.超薄二维纳米材料。
ACS Nano. 2015 Oct 27;9(10):9451-69. doi: 10.1021/acsnano.5b05040. Epub 2015 Sep 25.
Zotero 插件