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瘦素和胃饥饿素在外周血自然杀伤细胞表型调节及细胞因子产生中的作用

Roles of leptin and ghrelin in the regulation of the phenotype and cytokine production by NK cells from peripheral blood.

作者信息

Shirshev S V, Nekrasova I V, Orlova E G, Gorbunova O L

机构信息

Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences, Perm, 614081, Russia.

出版信息

Dokl Biol Sci. 2016 Sep;470(1):249-252. doi: 10.1134/S0012496616050136. Epub 2016 Nov 8.

DOI:10.1134/S0012496616050136
PMID:27822754
Abstract

Both leptin and ghrelin used separately at the concentrations corresponding to trimesters II-III of pregnancy increase the number of CD56 NK cells in mononuclear cell suspension; their combination also enhances the L-selectin expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-β1, IL-17А, or IFN-γ by NK cells, and they inhibit the production of IL-10. Leptin decreses the IL-4 production by NKp46 cells, but the presence of ghrelin abrogates this effect.

摘要

在与妊娠第二至三期相对应的浓度下单独使用瘦素和胃饥饿素，均可增加单核细胞悬液中CD56自然杀伤（NK）细胞的数量；二者联合使用还可增强培养物中这些细胞表面L-选择素的表达。这些激素不影响NK细胞产生转化生长因子-β1（TGF-β1）、白细胞介素-17A（IL-17А）或干扰素-γ（IFN-γ），且会抑制白细胞介素-10（IL-10）的产生。瘦素可降低NKp46细胞产生白细胞介素-4（IL-4），但胃饥饿素的存在可消除这种作用。

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本文引用的文献

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The role of pregnancy-associated hormones in regulation of expression of molecules responsible for NK cell functional activity.妊娠相关激素在调节自然杀伤细胞功能活性相关分子表达中的作用。
Dokl Biol Sci. 2014 Jul;457(1):261-4. doi: 10.1134/S0012496614040115. Epub 2014 Aug 30.
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Interaction between energy homeostasis and reproduction: central effects of leptin and ghrelin on the reproductive axis.能量平衡与生殖之间的相互作用：瘦素和胃饥饿素对生殖轴的中枢作用。
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Expression, regulation and biological actions of growth hormone (GH) and ghrelin in the immune system.生长激素（GH）和胃饥饿素在免疫系统中的表达、调节及生物学作用。
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The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy.人类妊娠中细胞毒性自然杀伤细胞与调节性自然杀伤细胞之间的平衡。
J Reprod Immunol. 2008 Jan;77(1):14-22. doi: 10.1016/j.jri.2007.04.007. Epub 2007 Jun 11.
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TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells.转化生长因子β促进CD16⁺外周血自然杀伤细胞转变为与蜕膜自然杀伤细胞相似的CD16⁻自然杀伤细胞。
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