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窄谱中波紫外线治疗前后银屑病患者的血清C反应蛋白水平

C-reactive protein serum level in patients with psoriasis before and after treatment with narrow-band ultraviolet B.

作者信息

Farshchian Mahmoud, Ansar Akram, Sobhan Mohammadreza, Hoseinpoor Valiollah

机构信息

Psoriasis Research Center, Department of Dermatology, Farshchian Hospital, Hamadan University of Medical Sciences - Hamadan, Iran.

出版信息

An Bras Dermatol. 2016 Sep-Oct;91(5):580-583. doi: 10.1590/abd1806-4841.20164655.

DOI:10.1590/abd1806-4841.20164655
PMID:27828628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5087213/
Abstract

BACKGROUND

: C-reactive protein is an inflammatory biomarker and its level increases in the serum of psoriatic patients. Its level is also associated with Psoriasis Area and Severity Index score.

OBJECTIVE

: The aim of this study was to assess the decrement of serum C-reactive protein level with narrow-band ultraviolet B (NB-UVB) therapy.

METHODS

: C-reactive protein serum levels in psoriasis patients were measured before and after treatment with NB-UVB and the data were analyzed in relation to the Psoriasis Area and Severity Index score improvement.

RESULTS

: Baseline C-reactive protein levels among psoriatic patients were higher than normal. These levels decreased significantly after treatment (P<0.001). At the beginning of the study, patients with higher levels of C-reactive protein also had more extensive and severe skin involvement. The highest decrease in C-reactive protein was observed in patients who responded better to the treatment and achieved a higher Psoriasis Area and Severity Index 75%. There was an association between baseline Psoriasis Area and Severity Index scores and C-reactive protein levels.

CONCLUSION

: Patients with moderate to severe plaque-type psoriasis had active systemic inflammation, which was demonstrated by increased levels of C-reactive protein. Furthermore, skin disease severity was correlated with C-reactive protein levels. Phototherapy healed the psoriatic skin lesions and reduced inflammation, while decreasing C-reactive protein levels.

摘要

背景

C反应蛋白是一种炎症生物标志物，其水平在银屑病患者血清中升高。其水平还与银屑病面积和严重程度指数评分相关。

目的

本研究旨在评估窄谱中波紫外线（NB-UVB）治疗后血清C反应蛋白水平的下降情况。

方法

测量银屑病患者接受NB-UVB治疗前后的血清C反应蛋白水平，并结合银屑病面积和严重程度指数评分的改善情况对数据进行分析。

结果

银屑病患者的基线C反应蛋白水平高于正常水平。治疗后这些水平显著下降（P<0.001）。在研究开始时，C反应蛋白水平较高的患者皮肤受累也更广泛、更严重。在对治疗反应较好且银屑病面积和严重程度指数达到75%以上的患者中，观察到C反应蛋白下降幅度最大。基线银屑病面积和严重程度指数评分与C反应蛋白水平之间存在关联。

结论

中度至重度斑块型银屑病患者存在活跃的全身炎症，这通过C反应蛋白水平升高得以证明。此外，皮肤病严重程度与C反应蛋白水平相关。光疗治愈了银屑病皮肤病变并减轻了炎症，同时降低了C反应蛋白水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/9e9872161f4e/abd-91-05-0580-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/e7cba4ba8ee5/abd-91-05-0580-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/1f3c626d31e4/abd-91-05-0580-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/9e9872161f4e/abd-91-05-0580-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/e7cba4ba8ee5/abd-91-05-0580-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/1f3c626d31e4/abd-91-05-0580-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cf8/5087213/9e9872161f4e/abd-91-05-0580-g03.jpg

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