Silva C, Olate S, Pozzer L, Muñoz M, Cantín M, Uribe F, de Albergaría-Barbosa J R
Division of Oral and Maxillofacial Surgery, State University of Campinas, Campinas, Brazil.
Division of Oral and Maxillofacial Surgery, Universidad de La Frontera, Temuco, Chile.
Int J Morphol. 2015 Sep;33(3):1146-1150. doi: 10.4067/S0717-95022015000300054.
Electrical stimulation has been used in different conditions for tissue regeneration. The aim of this study was to analyze the tissue response of defects created in rabbit skulls to electrical stimulation. Two groups were formed, each with 9 New Zealand rabbits; two 5 mm defects were made, one in each parietal, with one being randomly filled with autogenous bone extracted as particles and the other maintained only with blood clotting. The rabbits were euthanized at 8 weeks and 15 weeks to then study the samples collected histologically. In the 8-week analysis bone formation was observed in the defects in the test and control filled with bone graft, whereas the defects with clotting presented a very early stage of bone formation with abundant connective tissue. At 15 weeks an advanced stage of bone regeneration was identified in the defects with bone graft, whereas no significant differences were found in the electrically stimulated defects. In conclusion, electrical stimulus does not alter the sequence of bone formation; new studies could help establish patterns and influences of the stimulus on bone regeneration.
电刺激已被用于不同情况下的组织再生。本研究的目的是分析兔颅骨缺损对电刺激的组织反应。将兔子分为两组，每组9只；在每只兔子的顶骨上制造两个5毫米的缺损，其中一个随机填充自体骨颗粒，另一个仅保留血凝块。在8周和15周时对兔子实施安乐死，然后对收集的样本进行组织学研究。在8周的分析中，在填充骨移植的试验组和对照组缺损中观察到骨形成，而有血凝块的缺损呈现出骨形成的非常早期阶段，伴有丰富的结缔组织。在15周时，在有骨移植的缺损中发现了骨再生的晚期阶段，而在电刺激的缺损中未发现显著差异。总之，电刺激不会改变骨形成的顺序；新的研究可能有助于确定刺激对骨再生的模式和影响。
