Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, MD.
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
J Neurosci Res. 2018 Sep;96(9):1467-1475. doi: 10.1002/jnr.23978. Epub 2016 Nov 12.
The neuronal circuits defined by the axonal projections of pyramidal neurons in the cerebral cortex are responsible for processing sensory and other information to plan and execute behavior. Subtypes of cortical pyramidal neurons are organized across layers, with those in different layers distinguished by their patterns of axonal projections and connectivity. For example, those in layers 2 and 3 project between cortical areas to integrate sensory and other information with motor areas; while those in layers 5 and 6 also integrate information between cortical areas, but also project to subcortical structures involved in the generation of behavior. Recent advances in neuroanatomical techniques allow one to target specific subtypes of cortical pyramidal neurons and label both their inputs and projections. Combining these methods with neurophysiological recording techniques and newly introduced atlases of the mouse brain provide the opportunity to achieve a detailed view of the organization of cerebral cortical circuits. © 2016 Wiley Periodicals, Inc.
大脑皮层锥体神经元的轴突投射所定义的神经元回路负责处理感觉和其他信息，以规划和执行行为。皮质锥体神经元的亚型在不同的层中组织，其轴突投射和连接模式区分了不同的层。例如，位于 2 层和 3 层的锥体神经元在皮层区域之间投射，以将感觉和其他信息与运动区域整合；而位于 5 层和 6 层的锥体神经元也整合皮层区域之间的信息，但也投射到参与行为产生的皮质下结构。神经解剖学技术的最新进展允许靶向特定的皮质锥体神经元亚型，并标记其输入和投射。将这些方法与神经生理学记录技术以及新引入的小鼠大脑图谱相结合，为实现对大脑皮层回路组织的详细观察提供了机会。© 2016 Wiley Periodicals, Inc.
