Dutra-Behrens María, Schmeda-Hirschmann Guillermo
Departamento de Produtos Naturais, Instituto de Tecnologia em Fármacos da Fundação Oswaldo Cruz-Farmanguinhos/Fiocruz, Rua Sizenando Nabuco 100, 21041-250 Rio de Janeiro, Brazil.
Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, 3460000 Talca, Chile.
Molecules. 2016 Nov 21;21(11):1589. doi: 10.3390/molecules21111589.
The roots of the South American vine Klotzsch ex Griseb. (Herreriaceae) are used in traditional medicine by several Amerindian groups of the Paraguayan Chaco. Little is known on the chemistry of the plant, despite its widespread use across the South American Chaco. From the ethyl acetate/methanol 1:1 extract of the roots, four new and one known homoisoflavanoid, two flavan derivatives, a stilbene, a new alkaloid, and three new and four known spirostane steroids were isolated. The corresponding structures were elucidated by spectroscopic and spectrometric means. The homoisoflavonoids of the plant are related to compounds isolated from the Dracaenaceae (formerly Agavaceae) sources of the Chinese crude drug Dragon's Blood. The new alkaloid is a novel skeleton that can be used as a chemical marker of . The spirostane steroids suggest chemotaxonomic relations with the Liliales. This is the first comprehensive report on the chemistry of a South American species.
南美洲藤本植物克洛茨施氏藤（Klotzsch ex Griseb.，赫雷里亚科）的根被巴拉圭查科地区的几个美洲印第安人群体用于传统医学。尽管这种植物在南美洲查科地区广泛使用，但人们对其化学性质知之甚少。从该植物根的乙酸乙酯/甲醇1:1提取物中，分离出了四种新的和一种已知的高异黄酮、两种黄烷衍生物、一种芪、一种新生物碱以及三种新的和四种已知的螺甾烷甾体。通过光谱和波谱手段阐明了相应的结构。该植物的高异黄酮与从中国中药材血竭的龙舌兰科（原龙舌兰科）来源分离出的化合物有关。这种新生物碱是一种新型骨架，可作为……的化学标记物。螺甾烷甾体表明与百合目存在化学分类学关系。这是关于一种南美洲植物化学性质的首份全面报告。
