用于诊断的金纳米颗粒：迈向即时检测的进展。
Gold Nanoparticles for Diagnostics: Advances towards Points of Care.
作者信息
Cordeiro Mílton, Ferreira Carlos Fábio, Pedrosa Pedro, Lopez António, Baptista Pedro Viana
机构信息
UCIBIO, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
Rede de Química e Tecnologia (REQUIMTE), Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
出版信息
Diagnostics (Basel). 2016 Nov 22;6(4):43. doi: 10.3390/diagnostics6040043.
The remarkable physicochemical properties of gold nanoparticles (AuNPs) have prompted developments in the exploration of biomolecular interactions with AuNP-containing systems, in particular for biomedical applications in diagnostics. These systems show great promise in improving sensitivity, ease of operation and portability. Despite this endeavor, most platforms have yet to reach maturity and make their way into clinics or points of care (POC). Here, we present an overview of emerging and available molecular diagnostics using AuNPs for biomedical sensing that are currently being translated to the clinical setting.
金纳米颗粒（AuNPs）卓越的物理化学性质推动了对含AuNP系统与生物分子相互作用的探索，特别是在诊断方面的生物医学应用。这些系统在提高灵敏度、操作简便性和便携性方面显示出巨大潜力。尽管付出了这些努力，但大多数平台尚未成熟，也尚未进入临床或护理点（POC）。在此，我们概述了目前正在转化为临床应用的、利用AuNPs进行生物医学传感的新兴和现有分子诊断方法。
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