Song Shaozhen, Wei Wei, Hsieh Bao-Yu, Pelivanov Ivan, Shen Tueng T, O'Donnell Matthew, Wang Ruikang K
Department of Bioengineering, University of Washington , Seattle, Washington 98195, USA.
Appl Phys Lett. 2016 May 9;108(19):191104. doi: 10.1063/1.4949469. Epub 2016 May 10.
We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628 MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain fields can be mapped with ∼3.0 nm sensitivity at ∼16 000 fps. The system's capabilities are demonstrated on porcine cornea by imaging mechanical wave propagation launched by a pulsed UV laser beam, promising non-contact, real-time, and high-resolution optical coherence elastography.
我们展示了在组织内传播的机械波的单次相敏成像，这是由一个由1.628 MHz傅里叶域锁模（FDML）扫描激光源驱动的超快光学相干断层扫描（OCT）系统实现的。我们提出了一种通过比较相邻OCT B扫描之间的相位进行相敏测量的实用策略，其中B扫描包含的A扫描数量等于FDML缓冲区的整数倍。通过这种方法，我们表明可以在约16 000帧/秒的速度下以约3.0 nm的灵敏度绘制微应变场。通过对脉冲紫外激光束激发的机械波传播进行成像，在猪角膜上展示了该系统的能力，有望实现非接触、实时和高分辨率的光学相干弹性成像。
