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1060纳米紧凑型无运动伪像扫频源光学相干断层扫描血管造影术，支持后眼的宽视野和自适应光学成像模式。

Compact akinetic swept source optical coherence tomography angiography at 1060 nm supporting a wide field of view and adaptive optics imaging modes of the posterior eye.

作者信息

Salas Matthias, Augustin Marco, Felberer Franz, Wartak Andreas, Laslandes Marie, Ginner Laurin, Niederleithner Michael, Ensher Jason, Minneman Michael P, Leitgeb Rainer A, Drexler Wolfgang, Levecq Xavier, Schmidt-Erfurth Ursula, Pircher Michael

机构信息

Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.

Christian Doppler Laboratory for Innovative Optical Imaging and Its Translation to Medicine, Medical University of Vienna, Vienna, Austria.

出版信息

Biomed Opt Express. 2018 Mar 26;9(4):1871-1892. doi: 10.1364/BOE.9.001871. eCollection 2018 Apr 1.

DOI:10.1364/BOE.9.001871
PMID:29675326
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5905931/
Abstract

Imaging of the human retina with high resolution is an essential step towards improved diagnosis and treatment control. In this paper, we introduce a compact, clinically user-friendly instrument based on swept source optical coherence tomography (SS-OCT). A key feature of the system is the realization of two different operation modes. The first operation mode is similar to conventional OCT imaging and provides large field of view (FoV) images (up to 45° × 30°) of the human retina and choroid with standard resolution. The second operation mode enables it to optically zoom into regions of interest with high transverse resolution using adaptive optics (AO). The FoV of this second operation mode (AO-OCT mode) is 3.0° × 2.8° and enables the visualization of individual retinal cells such as cone photoreceptors or choriocapillaris. The OCT engine is based on an akinetic swept source at 1060 nm and provides an A-scan rate of 200 kHz. Structural as well as angiographic information can be retrieved from the retina and choroid in both operational modes. The capabilities of the prototype are demonstrated in healthy and diseased eyes.

摘要

对人类视网膜进行高分辨率成像，是改善诊断和治疗控制的关键一步。在本文中，我们介绍了一种基于扫频源光学相干断层扫描（SS-OCT）的紧凑型、临床易用型仪器。该系统的一个关键特性是实现了两种不同的操作模式。第一种操作模式类似于传统的OCT成像，可提供具有标准分辨率的人视网膜和脉络膜的大视野（FoV）图像（高达45°×30°）。第二种操作模式使其能够使用自适应光学（AO）以高横向分辨率光学变焦到感兴趣区域。此第二种操作模式（AO-OCT模式）的FoV为3.0°×2.8°，能够可视化单个视网膜细胞，如视锥光感受器或脉络膜毛细血管。OCT引擎基于一个1060nm的无运动扫频源，提供200kHz的A扫描速率。在两种操作模式下均可从视网膜和脉络膜获取结构以及血管造影信息。该原型的性能在健康和患病眼睛中得到了验证。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ea/5905931/4d7846b332b0/boe-9-4-1871-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ea/5905931/4d7846b332b0/boe-9-4-1871-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5ea/5905931/8badee11cb0b/boe-9-4-1871-g008.jpg
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3
Multiscale sensorless adaptive optics OCT angiography system for in vivo human retinal imaging.
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