Direction of Environmental Health, Santé Publique France, Saint Maurice Cedex, France.
Direction of Environmental Health, Santé Publique France, Saint Maurice Cedex, France.
Int J Hyg Environ Health. 2017 Mar;220(2 Pt A):64-70. doi: 10.1016/j.ijheh.2016.11.005. Epub 2016 Nov 17.
This paper presents a progress report of the French human biomonitoring (HBM) program established in 2010. This program has been designed to provide a national representative estimation of the French population's exposure to various environmental chemicals and to study the determinants of exposure. This program currently consists in two surveys: a perinatal component related to a selection of 4145 pregnant women who have been enrolled in the Elfe cohort (the French Longitudinal Study since Childhood) in 2011, and a general population survey related to adults aged 18-74 years and children as from 6 years (Esteban). The aim of this manuscript is to present highlights of the French human biomonitoring program with particular focus on the prioritization of biomarkers to be analyzed in the program and the selection of biomarkers applied to both program components. The Delphi method was used to establish a consensual list of prioritized biomarkers in 2011. First results of the perinatal component of the French HBM program have shown that the biomarkers prioritized were relevant, as almost all pregnant women were exposed to them. However, for some biomarkers, levels' decreases have been observed which may partly be explained by measures taken to prohibit some of these chemicals (e.g. atrazine) and by industrial processes evolutions leading to the substitution of others (e.g. bisphenol A, di-2-ethylhexyl phthalate/DEHP, dialkyl phosphates). Therefore, the list of biomarkers to be monitored in the French HBM program has been implemented to include some substitutes of biomarkers prioritized in the first instance (e.g. bisphenol S, F). Finally, this method combines rigor and flexibility and helped us to build a prioritized list that will be shared and supported by many if not all actors.
这篇论文介绍了 2010 年建立的法国人体生物监测（HBM）计划的进展报告。该计划旨在提供法国人口对各种环境化学物质暴露的全国代表性估计，并研究暴露的决定因素。该计划目前由两个调查组成：一个与 2011 年纳入 Elfe 队列（法国儿童纵向研究）的 4145 名孕妇相关的围产期部分，以及一个与 18-74 岁成年人和 6 岁以上儿童相关的一般人群调查（Esteban）。本文的目的是介绍法国人体生物监测计划的重点，特别关注计划中要分析的生物标志物的优先级以及应用于两个计划部分的生物标志物的选择。2011 年使用 Delphi 方法建立了优先生物标志物的共识清单。法国 HBM 计划围产期部分的初步结果表明，优先考虑的生物标志物是相关的，因为几乎所有孕妇都接触过这些生物标志物。然而，对于一些生物标志物，已经观察到水平下降，这部分可能是由于采取了一些措施禁止这些化学物质（例如莠去津）以及工业过程的发展导致其他物质（例如双酚 A、邻苯二甲酸二（2-乙基己基）酯/DEHP、烷基磷酸酯）的替代。因此，法国 HBM 计划中要监测的生物标志物清单已实施，包括最初优先考虑的一些生物标志物的替代品（例如双酚 S、F）。最后，这种方法结合了严谨性和灵活性，帮助我们建立了一个优先清单，该清单将得到许多（如果不是全部）参与者的共享和支持。
