Department of Paediatrics, Innlandet Hospital Trust, Lillehammer, Norway.
Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway.
Matern Child Nutr. 2017 Oct;13(4). doi: 10.1111/mcn.12405. Epub 2016 Dec 7.
In Norway, there were parallel increases and subsequent decreases in birth weight (BW) and consumption of sugar-sweetened carbonated soft drinks (SSC) during the period 1990-2010, and by an ecological approach, we have suggested that the relationship was causal. The objective of this study was to examine if such a relationship was present in a prospectively followed cohort of pregnant women. The study population included 62,494 term singleton mother-infant dyads in the Norwegian Mother and Child Cohort Study (MoBa), a national prospective cohort study in Norway from 1999 to 2008. The association between SSC consumption and BW was assessed using multiple regression analyses with adjustment for potential confounders. Each 100 ml intake of SSC was associated with a 7.8 g (95% confidence interval [CI]: -10.3 to -5.3) decrease in BW, a decreased risk of BW > 4,500 g (odds ratio [OR]: 0.94, 95% CI: 0.90 to 0.97) and a near significantly increased risk of BW < 2,500 g (OR: 1.05, 95% CI: 0.99 to 1.10). The negative association with SSC consumption was aggravated by smoking, lack of exercise, and obesity. For mothers with gestational diabetes mellitus, we observed an increased risk of BW > 4,500 g (OR: 1.18, 95% CI: 1.00 to 1.39) and a trend towards significant increase in mean BW (25.1 g, 95% CI: -2.0 to 52.2) per 100 ml SSC. Our findings suggest that increasing consumption of rapidly absorbed sugar from SSC had opposite associations with BW in normal pregnancies and pregnancies complicated by gestational diabetes mellitus.
在挪威，1990 年至 2010 年间，出生体重（BW）和糖饮料（SSC）的消耗量呈平行上升和随后下降的趋势，通过生态方法，我们提出这种关系是因果关系。本研究的目的是检查这种关系是否存在于前瞻性随访的孕妇队列中。该研究人群包括来自挪威的 1999 年至 2008 年的全国性前瞻性队列研究挪威母婴队列研究（MoBa）中的 62494 名足月单胎母婴对。使用多元回归分析，调整潜在混杂因素，评估 SSC 消耗与 BW 之间的关联。SSC 摄入每增加 100ml，BW 下降 7.8g（95%置信区间[CI]：-10.3 至-5.3），BW>4500g 的风险降低（比值比[OR]：0.94，95%CI：0.90 至 0.97），BW<2500g 的风险增加（OR：1.05，95%CI：0.99 至 1.10）。SSC 消耗与 BW 之间的负相关关系因吸烟、缺乏运动和肥胖而加重。对于患有妊娠期糖尿病的母亲，我们观察到 BW>4500g 的风险增加（OR：1.18，95%CI：1.00 至 1.39），以及 BW 均值（25.1g，95%CI：-2.0 至 52.2）每增加 100ml SSC 呈显著增加趋势。我们的研究结果表明，从 SSC 中摄取快速吸收的糖会对正常妊娠和妊娠期糖尿病合并妊娠的 BW 产生相反的影响。
