McLean B N, Rudge P, Thompson E J
Department of Neurochemistry, Queen Square, London, UK.
J Neurol. 1989 Sep;236(6):351-2. doi: 10.1007/BF00314379.
The cerebrospinal fluid (CSF) from seven West Indian migrants to the United Kingdom with tropical spastic paraparesis were studied by antigen immunoblotting for specific anti-HTLV1 oligoclonal IgG and IgM. Eight CSFs from five patients were positive for specific IgG and negative for IgM; three CSFs from two patients were positive for IgM and negative for IgG. No patient had both IgG- and IgM-positive CSF. Those patients with IgM only had disease of the shortest duration. When looking for evidence that neurological damage is caused by HTLV1, both IgM and IgG should be examined.
对七名从西印度群岛移民到英国并患有热带痉挛性截瘫的患者的脑脊液（CSF）进行了研究，通过抗原免疫印迹法检测特异性抗-HTLV1寡克隆IgG和IgM。五名患者的八份脑脊液中特异性IgG呈阳性，IgM呈阴性；两名患者的三份脑脊液中IgM呈阳性，IgG呈阴性。没有患者的脑脊液同时IgG和IgM均呈阳性。仅IgM阳性的患者病程最短。在寻找神经系统损伤由HTLV1引起的证据时，应同时检测IgM和IgG。
