Ghafoor Bakhtawar, Ali Murtaza Najabat, Ansari Umar, Bhatti Muhammad Faraz, Mir Mariam, Akhtar Hafsah, Darakhshan Fatima
Biomedical Engineering and Sciences Department, School of Mechanical and Manufacturing Engineering (SMME), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
Int J Biomater. 2016;2016:6964938. doi: 10.1155/2016/6964938. Epub 2016 Nov 14.
The study focuses on the development of novel based polymeric composite films and antimicrobial suture coatings. Polyvinyl alcohol (PVA), a synthetic biocompatible and biodegradable polymer, was combined with , a natural herb used for soothing burning effects and cosmetic purposes. The properties of these two materials were combined together to get additional benefits such as wound healing and prevention of surgical site infections. PVA and were mixed in a fixed quantity to produce polymer based films. The films were screened for antibacterial and antifungal activity against bacterial (, ) and fungal strains ( and ) screened. based PVA films showed antimicrobial activity against all the strains; the lowest concentration (5%) showed the highest activity against all the strains. degradation and release profile of these films was also evaluated. The coating for sutures was prepared, antibacterial tests of these coated sutures were carried out, and later on studies of these coated sutures were also performed. The results showed that sutures coated with /PVA coating solution have antibacterial effects and thus have the potential to be used in the prevention of surgical site infections and /PVA based films have the potential to be used for wound healing purposes.
该研究聚焦于新型聚合物基复合薄膜和抗菌缝合线涂层的开发。聚乙烯醇（PVA）是一种合成的生物相容性和可生物降解聚合物，它与一种用于舒缓灼烧效果和美容目的的天然草药相结合。将这两种材料的特性组合在一起，以获得诸如伤口愈合和预防手术部位感染等额外益处。将PVA和该草药按固定量混合以制备聚合物基薄膜。对这些薄膜针对筛选出的细菌（如大肠杆菌、金黄色葡萄球菌）和真菌菌株（白色念珠菌和黑曲霉）进行抗菌和抗真菌活性筛选。该草药基PVA薄膜对所有菌株均显示出抗菌活性；最低浓度（5%）对所有菌株显示出最高活性。还评估了这些薄膜的降解和释放情况。制备了缝合线涂层，对这些涂层缝合线进行了抗菌测试，随后还对这些涂层缝合线进行了研究。结果表明，涂有该草药/PVA涂层溶液的缝合线具有抗菌作用，因此有潜力用于预防手术部位感染，且该草药/PVA基薄膜有潜力用于伤口愈合目的。
