呋甾酮 A 和 B，两种来源于内生真菌 Phomopsis sp. TJ507A 的具功能基的麦角甾烷型甾体化合物。
Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.
出版信息
Org Lett. 2017 Jan 6;19(1):258-261. doi: 10.1021/acs.orglett.6b03557. Epub 2016 Dec 22.
Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures were determined on the basis of spectroscopic data, a modified Mosher's method, X-ray crystallographic analysis, and quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring a rearranged bicyclo[3.3.1]nonane motif resulting from B-ring scission and a subsequent 180° rotation of the ring A during biosynthesis. Compound 2 exhibited anti-inflammatory activity.
从植物来源的 Phomopsis sp. TJ507A 中分离得到两种新的功能化麦角甾烷型甾体化合物 phomopsterones A（1）和 B（2）。根据光谱数据、改进的 Mosher 法、X 射线晶体学分析和量子化学计算确定了它们的结构。化合物 1 是一种前所未有的麦角甾醇，其特征在于由于 B 环断裂和随后的环 A 在生物合成过程中发生 180°旋转，导致双环[3.3.1]壬烷骨架重排。化合物 2 表现出抗炎活性。
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