Wytrykowska Anna, Prosba-Mackiewicz Maria, Nyka Walenty M
Department of Dental Techniques and Dysfunction of Masticatory System, Medical University of Gdansk.
J Oral Sci. 2016;58(4):509-513. doi: 10.2334/josnusd.16-0278.
It has been documented that an increase of immune cells in periodontitis may stimulate the process of atherosclerosis and lead to ischemic stroke. The aim of this study was to investigate whether there is any significant difference in serum and gingival crevicular fluid (GCF) cytokine concentrations between patients with early ischemic stroke (IS) and a control group. Eighty-six patients were consecutively enrolled for this study, 50 with ischemic stroke and 36 as a control group with no previous stroke. Only dentulous patients were included. In each patient, GCF was collected from the deepest periodontal pocket. Blood serum samples were also taken from all subjects. The collected material was analyzed for cytokine concentrations using the cytometric bead array technique. Cerebral ischemia was found to be correlated with higher serum levels of IL-1β (13.01 ± 13.87 vs. 7.83 ± 2.11) and IL-6 (15.82 ± 16.64 vs. 6.64 ± 2.5) compared to the control group. The levels of IL-1, IL-6 and TNF-α in GCF were higher in patients with ischemic stroke but the difference was not significant. In conclusion, ischemic stroke was found to be associated with higher levels of IL-1β and IL-6 in serum. The cytokine concentrations in GCF did not appear to be directly correlated with those in serum in patients with ischemic stroke.(J Oral Sci 58, 509-513, 2016).
据记载，牙周炎中免疫细胞的增加可能会刺激动脉粥样硬化进程并导致缺血性中风。本研究的目的是调查早期缺血性中风（IS）患者与对照组之间血清和龈沟液（GCF）细胞因子浓度是否存在显著差异。本研究连续纳入了86例患者，其中50例为缺血性中风患者，36例为无中风病史的对照组。仅纳入有牙患者。在每位患者中，从最深牙周袋收集龈沟液。还从所有受试者采集血清样本。使用细胞计数珠阵列技术分析所收集材料的细胞因子浓度。与对照组相比，发现脑缺血与血清中较高水平的IL-1β（13.01±13.87对7.83±2.11）和IL-6（15.82±16.64对6.64±2.5）相关。缺血性中风患者龈沟液中IL-1、IL-6和TNF-α水平较高，但差异不显著。总之，发现缺血性中风与血清中较高水平的IL-1β和IL-6相关。缺血性中风患者龈沟液中的细胞因子浓度似乎与血清中的细胞因子浓度没有直接相关性。（《口腔科学杂志》58卷，509 - 513页，2016年）
