Roohafza Hamidreza, Bidaki Ehsan Zare, Hasanzadeh-Keshteli Ammar, Daghaghzade Hamed, Afshar Hamid, Adibi Peyman
Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Integrative Functional Gastroenterology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2016 Nov 28;5:183. doi: 10.4103/2277-9175.190938. eCollection 2016.
Psychiatric disorders are common in irritable bowel syndrome (IBS). We conducted this study to investigate the relationship of IBS and their subtypes with some of psychological factors.
A cross-sectional study was performed among 4763 staff of Isfahan University of Medical Sciences in 2011. Modified ROME III questionnaire and Talley Bowel Disease Questionnaire were used to evaluate IBS symptoms. Hospital Anxiety and Depression Scale and 12-item General Health Questionnaire were utilized to assess anxiety, depression and psychological distress. Logistic regression analysis was used to determine the association of psychological states and IBS in the total subject and both genders.
About, 4763 participants with mean age 36/58 ± 8/09 were included the 2106 males and 2657 females. Three thousand and seven hundred and seventy-six (81.2%) and 2650 (57.2%) participants were married and graduated respectively. Subtype analysis of IBS and its relationship with anxiety, depression and distress comparing the two genders can be observed that: IBS and clinically-significant IBS have higher anxiety, depression symptoms, and distress than the subject without IBS ( < 0.001). Women with IBS, have higher scores than men ( < 0.001). Compared to other subtypes, mixed IBS subtype has a higher anxiety, depression, and distress score.
A high prevalence of anxiety, depression symptoms and distress in our subjects emphasize the importance of the psychological evaluation of the patients with IBS, in order to better management of the patients and may also help to reduce the burden of health care costs.
精神障碍在肠易激综合征（IBS）中很常见。我们开展这项研究以调查IBS及其亚型与某些心理因素之间的关系。
2011年对伊斯法罕医科大学的4763名工作人员进行了一项横断面研究。采用改良的罗马III问卷和塔利肠道疾病问卷评估IBS症状。使用医院焦虑抑郁量表和12项一般健康问卷评估焦虑、抑郁和心理困扰。采用逻辑回归分析确定心理状态与IBS在总体研究对象及男女两性中的关联。
共纳入约平均年龄为36.58±8.09岁的4763名参与者，其中男性2106名，女性2657名。分别有3776名（81.2%）参与者已婚，2650名（57.2%）参与者毕业。对IBS及其与焦虑、抑郁和困扰的关系进行的两性亚型分析显示：IBS及具有临床意义的IBS比无IBS的研究对象有更高的焦虑、抑郁症状及困扰（P<0.001）。IBS女性的得分高于男性（P<0.001）。与其他亚型相比，混合型IBS亚型的焦虑、抑郁和困扰得分更高。
我们研究对象中焦虑、抑郁症状及困扰的高患病率强调了对IBS患者进行心理评估的重要性，以便更好地管理患者，也可能有助于减轻医疗保健成本负担。
