Cirlini Martina, Mazzeo Teresa, Roncoroni Leda, Lombardo Vincenza, Elli Luca, Bardella Maria T, Agostoni Carlo, Doneda Luisa, Brighenti Furio, Dall'Asta Chiara, Pellegrini Nicoletta
Department of Food Science, University of Parma, Parco Area delle Scienze, 49/A, Parma 43124, Italy.
Center for Prevention and Diagnosis of Celiac Disease, Gastroenterology and Endoscopy Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.
Toxins (Basel). 2016 Dec 28;9(1):11. doi: 10.3390/toxins9010011.
Urinary biomarkers of mycotoxin exposure were evaluated in a group of celiac patients ( = 55) and in a control group of healthy subjects ( = 50) following their habitual diet. Deoxynivalenol (DON), zearalenone (ZEN), and fumonisin B1 (FB1) were monitored in 105 urinary samples collected from the two groups. Dietary habits were also recorded through compilation of a seven-day weighed dietary diary. Biomarkers of mycotoxin exposure were detected in 21 celiac patients and in 15 control subjects, corresponding to about 34% of total participants. In particular, ZEN was the most detected mycotoxin among all the studied subjects with a total of 19 positive cases. Results did not show a statistically significant difference in mycotoxin exposure between the two groups, and the presence of specific mycotoxins was not related to the intake of any particular food category. Our findings suggest little urgency of specific regulation for gluten free products, although the prevalence of exposure observed in free-living diets of both celiac and healthy subjects underlines the need of a constant surveillance on mycotoxins occurrence at large.
在一组乳糜泻患者（n = 55）和一组遵循日常饮食的健康对照受试者（n = 50）中评估了霉菌毒素暴露的尿液生物标志物。在从两组收集的105份尿液样本中监测了脱氧雪腐镰刀菌烯醇（DON）、玉米赤霉烯酮（ZEN）和伏马菌素B1（FB1）。还通过编制一份为期七天的称重饮食日记记录了饮食习惯。在21例乳糜泻患者和15例对照受试者中检测到霉菌毒素暴露生物标志物，约占总参与者的34%。特别是，ZEN是所有研究对象中检测到最多的霉菌毒素，共有19例阳性病例。结果显示两组之间霉菌毒素暴露没有统计学上的显著差异，并且特定霉菌毒素的存在与任何特定食物类别的摄入量无关。我们的研究结果表明，尽管在乳糜泻患者和健康受试者的自由生活饮食中观察到的暴露患病率强调了对霉菌毒素普遍存在进行持续监测的必要性，但针对无麸质产品的特定监管紧迫性不大。
