Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
Psychiatry Res Neuroimaging. 2017 Feb 28;260:76-85. doi: 10.1016/j.pscychresns.2016.12.009. Epub 2016 Dec 16.
Fronto-limbic brain networks involved in regulation of impulsivity and aggression are abnormal in Borderline Personality Disorder (BPD). However, it is unclear whether, or to what extent, these personality traits actually modulate brain responses during cognitive processing. Using fMRI, we examined the effects of trait impulsivity, aggression, and depressed mood on regional brain responses in 31 female BPD and 25 control subjects during a Go No-Go task using Ekman faces as targets. First-level contrasts modeled effects of negative emotional context. Second-level regression models used trait impulsivity, aggression and depressed mood as predictor variables of regional brain activations. In BPD, trait impulsivity was positively correlated with activation in the dorsal anterior cingulate cortex, orbital frontal cortex (OFC), basal ganglia (BG), and dorsolateral prefrontal cortex, with no areas of negative correlation. In contrast, aggression was negatively correlated with activation in OFC, hippocampus, and BG, with no areas of positive correlation. Depressed mood had a generally dampening effect on activations. Effects of trait impulsivity on healthy controls differed from effects in BPD, suggesting a disorder-specific response. Negative emotional context and trait impulsivity, but not aggression or depression, diminished task performance across both groups. Negative emotional context may interfere with cognitive functioning in BPD through interaction with the neurobiology of personality traits.
边缘-额眶网络参与冲动和攻击的调节，在边缘型人格障碍（BPD）中异常。然而，目前尚不清楚这些人格特质是否以及在何种程度上调节认知加工过程中的大脑反应。使用 fMRI，我们在 31 名女性 BPD 和 25 名对照受试者中检查了特质冲动、攻击和抑郁情绪对情绪面孔为目标的 Go/No-Go 任务期间大脑区域反应的影响。一级对比模型模拟了负面情绪环境的影响。二级回归模型将特质冲动、攻击和抑郁情绪作为大脑区域激活的预测变量。在 BPD 中，特质冲动与背侧前扣带回皮质、眶额皮质（OFC）、基底节（BG）和背外侧前额叶皮质的激活呈正相关，无负相关区域。相比之下，攻击与 OFC、海马体和 BG 的激活呈负相关，无正相关区域。抑郁情绪对激活有普遍的抑制作用。特质冲动对健康对照组的影响与 BPD 中的影响不同，表明存在特定于疾病的反应。负面情绪环境和特质冲动，而不是攻击或抑郁，都降低了两组的任务表现。负面情绪环境可能通过与人格特质的神经生物学相互作用，干扰 BPD 中的认知功能。
