University Children's Hospital Zürich, Zürich, Switzerland.
Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands.
Sci Rep. 2017 Jan 4;7:39763. doi: 10.1038/srep39763.
Prior knowledge speeds up system consolidation and accelerates integration of newly acquired memories into existing neocortical knowledge networks. By using targeted memory reactivations, we demonstrate that prior knowledge is also essential for successful reactivation and consolidation of memories during sleep, both on the behavioral and oscillatory level (i.e., theta and fast spindle activity). Thus, prior knowledge is a prerequisite for new memories to enter processes of system consolidation during sleep.
先前的知识可以加速系统巩固，并加速新获得的记忆与现有的新皮质知识网络整合。通过有针对性的记忆再激活，我们证明了先前的知识对于睡眠期间记忆的成功再激活和巩固也是必不可少的，无论是在行为层面还是在振荡层面（即θ波和快速纺锤波活动）。因此，先前的知识是新记忆在睡眠中进入系统巩固过程的前提条件。
