Mannucci Carmen, Casciaro Marco, Minciullo Paola L, Calapai Gioacchino, Navarra Michele, Gangemi Sebastiano
Allergy Asthma Proc. 2017 Jan 1;38(1):9-15. doi: 10.2500/aap.2017.38.4013.
miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes.
To collect and review data from the literature on involvement of miRNA in inflammatory skin disorders.
A bibliographic search of scientific literature was carried out independently by two researchers in scientific data bases and search engines. The MeSH terms used were the following: "microRNAs" combined with "skin," "dermatitis," "urticaria," "eczema," "hypersensitivity." All research articles from inception until April 2016 were considered.
A total of 11 research articles on the study of miRNAs in inflammatory skin disorders (atopic dermatitis, delayed-type hypersensitivity, eczema, toxic epidermal necrolysis) were identified. All the studies confirmed the main role of endogenous noncoding RNAs in diseases such as atopic dermatitis, allergic contact dermatitis, eczema, and toxic epidermal necrolysis.
The miRNAs seem to influence regulatory mechanisms of inflammation in both inducing and contrasting acute and chronic skin inflammation. They also seem to be useful instruments in identifying and staging diseases such as dermatitis and other inflammatory skin diseases. Also, the potential application of miRNAs in genetic therapies demonstrated its efficacy on animal models.
微小RNA（miRNAs）是一类非编码RNA分子，可在转录后调节基因表达。已知miRNAs参与正常皮肤和患病皮肤的各种细胞过程。最近，有报道称miRNAs存在差异表达，并与多种免疫和炎症性疾病相关，这表明其在基本生物学过程中具有共同作用。
收集并综述文献中关于miRNA参与炎症性皮肤病的相关数据。
两名研究人员独立在科学数据库和搜索引擎中对科学文献进行书目检索。使用的医学主题词如下：“微小RNA”与“皮肤”“皮炎”“荨麻疹”“湿疹”“超敏反应”组合。纳入从创刊至2016年4月的所有研究文章。
共识别出11篇关于miRNAs在炎症性皮肤病（特应性皮炎、迟发型超敏反应、湿疹、中毒性表皮坏死松解症）研究方面的文章。所有研究均证实内源性非编码RNA在特应性皮炎、过敏性接触性皮炎、湿疹和中毒性表皮坏死松解症等疾病中起主要作用。
miRNAs似乎在诱导和对抗急慢性皮肤炎症方面影响炎症调节机制。它们似乎也是识别和分期皮炎等炎症性皮肤病的有用工具。此外，miRNAs在基因治疗中的潜在应用在动物模型上证明了其有效性。
