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使用激光散斑血流图评估正常个体和颈内动脉阻塞患者的眼底血流

Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy.

作者信息

Shinohara Yoichiro, Kashima Tomoyuki, Akiyama Hideo, Shimoda Yukitoshi, Li Danjie, Kishi Shoji

机构信息

Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan.

出版信息

PLoS One. 2017 Jan 5;12(1):e0169596. doi: 10.1371/journal.pone.0169596. eCollection 2017.

DOI:10.1371/journal.pone.0169596
PMID:28056061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5215808/
Abstract

PURPOSE

We investigated whether laser speckle flowgraphy (LSFG) results are comparable in both eyes and whether it is useful in the diagnosis of disparity in ocular ischemic syndrome (OIS) patients.

METHODS

We compared the mean blur rate (MBR) value for various fundus regions in both eyes of 41 healthy subjects and 15 internal carotid artery occlusion (ICAO) cases. We calculated the standard value of the Laterality Index (LI), which was the MBR comparison of both eyes in each of the regions, in the control subjects. We then investigated the correlation between both eyes for the LIs in the entire fundus, the degree of ICAO and visual function.

RESULTS

The disparity of the LIs in both eyes was least in the entire area of the fundus in control subjects and there was a significant correlation between both eyes of the 41 healthy individuals (P = 0.019). Significant correlations were found for the LI, visual acuity and degree of ICAO. The specificity and sensitivity of LI in the entire area was 93.8% and 100%, respectively.

CONCLUSIONS

LSFG revealed normal individuals have symmetrical fundus blood flow. LSFG could detect OIS and might be a useful tool for detecting disparities in fundus blood flow.

摘要

目的

我们研究了激光散斑血流图（LSFG）结果在双眼是否具有可比性，以及它在诊断眼部缺血综合征（OIS）患者的差异方面是否有用。

方法

我们比较了41名健康受试者和15例颈内动脉闭塞（ICAO）患者双眼不同眼底区域的平均模糊率（MBR）值。我们计算了对照组中各区域双眼MBR比较的偏侧性指数（LI）的标准值。然后我们研究了整个眼底LI的双眼之间、ICAO程度和视觉功能之间的相关性。

结果

对照组受试者整个眼底区域双眼LI的差异最小，41名健康个体的双眼之间存在显著相关性（P = 0.019）。发现LI、视力和ICAO程度之间存在显著相关性。整个区域LI的特异性和敏感性分别为93.8%和100%。

结论

LSFG显示正常个体的眼底血流是对称的。LSFG可以检测OIS，可能是检测眼底血流差异的有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/f030ca2cd9a9/pone.0169596.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/0def191dbee0/pone.0169596.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/fa51607d6622/pone.0169596.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/a42d31bef710/pone.0169596.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/372f642db97e/pone.0169596.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/f030ca2cd9a9/pone.0169596.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/0def191dbee0/pone.0169596.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/fa51607d6622/pone.0169596.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/a42d31bef710/pone.0169596.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/372f642db97e/pone.0169596.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/18bb/5215808/f030ca2cd9a9/pone.0169596.g005.jpg

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