Takafuji S, Suzuki S, Koizumi K, Tadokoro K, Ohashi H, Muranaka M, Miyamoto T
Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
Int Arch Allergy Appl Immunol. 1989;90(1):1-7. doi: 10.1159/000234990.
Suspended particulate matter (SPM), suspended in the polluted environmental atmosphere, are perpetually inhaled into the human body and are considered to have profound effects on human health. This study investigated the enhancing effect of SPM on the IgE antibody production in mice. The IgE antibody responses in mice immunized with intranasal administration of ovalbumin (OA) plus SPM at 3-week intervals were higher than responses in the animals immunized with OA alone. When the dose of OA administered as an antigen was 0.25 microgram, the time course and magnitude of enhancement by SPM was comparable to those by killed Bordetella pertussis, a common adjuvant. SPM had an enhancing effect on IgE antibody production even in a small dose such as 0.25 microgram administered at 3-week intervals. The possibility cannot be excluded that the natural exposure of humans to SPM in the environmental atmosphere may explain the high prevalence rate of allergic rhinitis caused by pollens in polluted districts in Japan.
悬浮颗粒物（SPM）悬浮于受污染的环境大气中，会不断被人体吸入，并被认为对人体健康有深远影响。本研究调查了SPM对小鼠体内IgE抗体产生的增强作用。每隔3周经鼻内给予卵清蛋白（OA）加SPM免疫的小鼠的IgE抗体反应高于仅用OA免疫的动物的反应。当作为抗原给予的OA剂量为0.25微克时，SPM增强作用的时间进程和幅度与常用佐剂百日咳杆菌灭活疫苗相当。即使以小剂量（如每隔3周给予0.25微克），SPM对IgE抗体产生也有增强作用。不能排除人类在环境大气中自然接触SPM可能是日本污染地区花粉引起的过敏性鼻炎高患病率的原因。
