转化生长因子-β1通过激活Hippo信号通路抑制肝细胞癌增殖。
Transforming growth factor-beta1 suppresses hepatocellular carcinoma proliferation via activation of Hippo signaling.
作者信息
Zhang Xiaodong, Fan Qing, Li Yan, Yang Zhaoguo, Yang Liang, Zong Zhihong, Wang Biao, Meng Xin, Li Qin, Liu Jingang, Li Hangyu
机构信息
Department of General Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, P. R. China.
Department of Oncology, Tumour Angiogenesis and Microenvironment Laboratory (TAML), The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, P. R. China.
出版信息
Oncotarget. 2017 May 2;8(18):29785-29794. doi: 10.18632/oncotarget.14523.
In this study, we examined the expression of core proteins of the Hippo signaling pathway in hepatocellular carcinoma (HCC) cells treated with transforming growth factor-β 1(TGF-β1) and investigated the relationship between TGF-β1 and the Hippo signaling pathway, in order to better understand their roles in HCC and their potential implications for cancer therapy. We prove that the Hippo signaling pathway is involved in the TGF-β1-induced inhibition of the growth of HCC cells. Large tumor suppressor expression (LATS1) was overexpression and yes association protein 1(YAP1) translocated from the nucleus to the cytoplasm in HCC cells treated with TGF-β1. Overexpression of LATS1 and the nucleocytoplasmic translocation of YAP1 play an anti-oncogenetic role in the occurrence and development of liver cancer. Our findings provide new insight into strategies for liver cancer therapy.
在本研究中，我们检测了用转化生长因子-β1（TGF-β1）处理的肝细胞癌（HCC）细胞中Hippo信号通路核心蛋白的表达，并研究了TGF-β1与Hippo信号通路之间的关系，以便更好地了解它们在肝癌中的作用及其对癌症治疗的潜在意义。我们证明Hippo信号通路参与了TGF-β1诱导的HCC细胞生长抑制。在用TGF-β1处理的HCC细胞中，大肿瘤抑制因子表达（LATS1）过表达，Yes相关蛋白1（YAP1）从细胞核转移到细胞质。LATS1的过表达和YAP1的核质转位在肝癌的发生发展中发挥着抗癌作用。我们的研究结果为肝癌治疗策略提供了新的见解。
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