Rose G
Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, UK.
Int J Epidemiol. 1989;18(3 Suppl 1):S174-9.
Rapid changes in national rates, with little evidence of cohort effects, must substantially reflect changes in incidence rates due to socioeconomic and behavioral influences, operating with a rather short incubation period. Every newly-rich society usually experiences its epidemic of coronary heart disease. Rate changes for men and women are correlated, but the regression is asymmetrical: greater falls in women seem to reflect some rather uniform widespread sex-specific change, on top of which is another and highly variable factor common to both sexes. Trends are correlated with diet (especially with the constitution of fats). A correlation with stroke trends suggests a common link with population changes in blood pressure, in which obesity may play a part. Other important influences on population trends and differences remain unidentified or unconfirmed.
各国发病率的快速变化,几乎没有队列效应的证据,这必然在很大程度上反映了由于社会经济和行为影响导致的发病率变化,且潜伏期较短。每个新富起来的社会通常都会经历冠心病的流行。男性和女性的发病率变化相关,但回归是不对称的:女性发病率的更大降幅似乎反映了一些相当一致的广泛的性别特异性变化,在此基础上还有另一个男女共有的高度可变因素。趋势与饮食(尤其是脂肪构成)相关。与中风趋势的相关性表明与人群血压变化存在共同联系,肥胖可能在其中起作用。对人群趋势和差异的其他重要影响仍未明确或未得到证实。