Kleckner Ian R, Zhang Jiahe, Touroutoglou Alexandra, Chanes Lorena, Xia Chenjie, Simmons W Kyle, Quigley Karen S, Dickerson Bradford C, Barrett Lisa Feldman
Department of Psychology, Northeastern University, Boston, MA.
Department of Neurology, Massachusetts General Hospital and Harvard Medical School.
Nat Hum Behav. 2017;1. doi: 10.1038/s41562-017-0069. Epub 2017 Apr 24.
Large-scale intrinsic brain systems have been identified for exteroceptive senses (e.g., sight, hearing, touch). We introduce an analogous system for representing sensations from within the body, called interoception, and demonstrate its relation to regulating peripheral systems in the body, called allostasis. Employing the recently introduced Embodied Predictive Interoception Coding (EPIC) model, we used tract-tracing studies of macaque monkeys, followed by two intrinsic functional magnetic resonance imaging samples ( = 280 and = 270) to evaluate the existence of an intrinsic allostatic/interoceptive system in the human brain. Another sample ( = 41) allowed us to evaluate the convergent validity of the hypothesized allostatic/interoceptive system by showing that individuals with stronger connectivity between system hubs performed better on an implicit index of interoceptive ability related to autonomic fluctuations. Implications include insights for the brain's functional architecture, dissolving the artificial boundary between mind and body, and unifying mental and physical illness.
大规模的内在脑系统已被确定用于外感受觉（如视觉、听觉、触觉）。我们引入了一个类似的系统来表示来自身体内部的感觉，称为内感受，并证明了它与调节身体外周系统（称为异稳态）的关系。利用最近引入的具身预测内感受编码（EPIC）模型，我们对猕猴进行了束路追踪研究，随后进行了两个内在功能磁共振成像样本研究（n = 280和n = 270），以评估人类大脑中是否存在内在的异稳态/内感受系统。另一个样本（n = 41）使我们能够通过表明系统枢纽之间连接性更强的个体在与自主波动相关的内感受能力的隐性指标上表现更好，来评估假设的异稳态/内感受系统的收敛效度。其意义包括对大脑功能结构的深入了解、消除身心之间的人为界限以及统一精神疾病和身体疾病。
