快照：2 类 CRISPR-Cas 系统。
SnapShot: Class 2 CRISPR-Cas Systems.
机构信息
National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894, USA.
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
出版信息
Cell. 2017 Jan 12;168(1-2):328-328.e1. doi: 10.1016/j.cell.2016.12.038.
PMID:28086097
Abstract
Class 2 CRISPR-Cas systems are characterized by effector modules consisting of single, large, multidomain proteins that appear to have been derived from mobile genetic elements. Some Class 2 effector proteins, such as Cas9 and Cas12a (Cpf1), have been successfully repurposed for genome engineering.
摘要
CRISPR-Cas 系统 2 类的特点是效应模块由单个、大型、多结构域蛋白组成，这些蛋白似乎来自于可移动的遗传元件。一些 2 类效应蛋白，如 Cas9 和 Cas12a（Cpf1），已被成功重新用于基因组工程。
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