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Adipose Tissue CLK2 Promotes Energy Expenditure during High-Fat Diet Intermittent Fasting.
Cell Metab. 2017 Feb 7;25(2):428-437. doi: 10.1016/j.cmet.2016.12.007. Epub 2017 Jan 12.
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In the absence of UCP1-mediated diet-induced thermogenesis, obesity is augmented even in the obesity-resistant 129S mouse strain.
Am J Physiol Endocrinol Metab. 2019 May 1;316(5):E729-E740. doi: 10.1152/ajpendo.00020.2019. Epub 2019 Feb 26.
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Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes.
J Nutr Biochem. 2017 Jan;39:101-109. doi: 10.1016/j.jnutbio.2016.08.012. Epub 2016 Sep 22.
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p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.
PLoS Biol. 2018 Jul 6;16(7):e2004455. doi: 10.1371/journal.pbio.2004455. eCollection 2018 Jul.
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Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning.
Diabetes. 2017 Jun;66(6):1611-1625. doi: 10.2337/db16-1079. Epub 2017 Mar 7.
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Quantification of UCP1 function in human brown adipose tissue.
Adipocyte. 2017 Apr 3;6(2):167-174. doi: 10.1080/21623945.2017.1319535. Epub 2017 Apr 14.
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Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice.
Biochem Biophys Res Commun. 2021 Apr 2;547:29-35. doi: 10.1016/j.bbrc.2021.01.103. Epub 2021 Feb 13.

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Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the Host and Microbiome.
Adv Nutr. 2025 May 16;16(7):100448. doi: 10.1016/j.advnut.2025.100448.
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Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice.
BMC Biol. 2024 Nov 20;22(1):268. doi: 10.1186/s12915-024-02061-2.
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Macrophages and T cells in metabolic disorder-associated cancers.
Nat Rev Cancer. 2024 Nov;24(11):744-767. doi: 10.1038/s41568-024-00743-1. Epub 2024 Oct 1.
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From fasting to fat reshaping: exploring the molecular pathways of intermittent fasting-induced adipose tissue remodeling.
J Pharm Pharm Sci. 2024 Jul 22;27:13062. doi: 10.3389/jpps.2024.13062. eCollection 2024.
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Intermittent fasting and health outcomes: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials.
EClinicalMedicine. 2024 Mar 11;70:102519. doi: 10.1016/j.eclinm.2024.102519. eCollection 2024 Apr.
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CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion.
Front Endocrinol (Lausanne). 2023 Aug 10;14:1172835. doi: 10.3389/fendo.2023.1172835. eCollection 2023.
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Functions of SRPK, CLK and DYRK kinases in stem cells, development, and human developmental disorders.
FEBS Lett. 2023 Oct;597(19):2375-2415. doi: 10.1002/1873-3468.14723. Epub 2023 Sep 4.
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Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation.
J Endocr Soc. 2023 Jun 17;7(7):bvad082. doi: 10.1210/jendso/bvad082. eCollection 2023 Jun 5.

本文引用的文献

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Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans.
Cell Metab. 2016 Apr 12;23(4):602-9. doi: 10.1016/j.cmet.2016.02.007. Epub 2016 Mar 10.
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Do intermittent diets provide physiological benefits over continuous diets for weight loss? A systematic review of clinical trials.
Mol Cell Endocrinol. 2015 Dec 15;418 Pt 2:153-72. doi: 10.1016/j.mce.2015.09.014. Epub 2015 Sep 16.
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Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response.
Nucleus. 2015;6(4):279-88. doi: 10.1080/19491034.2015.1062194. Epub 2015 Jun 22.
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Characterization of Cre recombinase models for the study of adipose tissue.
Adipocyte. 2014 Jul 1;3(3):206-11. doi: 10.4161/adip.29674. Epub 2014 Jun 27.
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The different shades of fat.
Nature. 2014 Jun 5;510(7503):76-83. doi: 10.1038/nature13477.
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Brown and beige fat: development, function and therapeutic potential.
Nat Med. 2013 Oct;19(10):1252-63. doi: 10.1038/nm.3361. Epub 2013 Sep 29.
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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
Cell Metab. 2012 Jun 6;15(6):848-60. doi: 10.1016/j.cmet.2012.04.019. Epub 2012 May 17.
9
Transcriptional control of adipose lipid handling by IRF4.
Cell Metab. 2011 Mar 2;13(3):249-59. doi: 10.1016/j.cmet.2011.02.005.
10
Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt.
Mol Cell. 2011 Feb 18;41(4):471-9. doi: 10.1016/j.molcel.2011.02.007.

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